Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ASIC3 | Q9UHC3 | 1/20 | 0.55 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.44 |
| ▸ | DYRK1A | Q13627 | 8/20 | 0.42 |
| ▸ | CDK9 | P50750 | 5/20 | 0.38 |
| ▸ | DYRK2 | Q92630 | 5/20 | 0.38 |
| ▸ | NOS3 | P29474 | 3/20 | 0.37 |
| ▸ | NOS1 | P29475 | 2/20 | 0.37 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | NOS2 | P35228 | 1/20 | 0.36 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.36 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.35 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.35 |
| ▸ | CSNK1E | P49674 | 2/20 | 0.35 |
| ▸ | CLK1 | P49759 | 2/20 | 0.35 |
| ▸ | CLK2 | P49760 | 2/20 | 0.35 |
| ▸ | CLK3 | P49761 | 2/20 | 0.35 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31052454 | 0.81 | ASIC3 (0.59) | ASIC3PDPK1NOS3NOS1MEN1 | |
| SCHEMBL901581 | 0.79 | MAP4K4 (0.52) | ASIC3PDPK1MEN1KMT2AADORA2B | |
| SCHEMBL3923558 | 0.76 | ASIC3 (0.62) | ASIC3PDPK1MEN1KMT2AADORA2B | |
| SCHEMBL2249475 | 0.75 | ASIC3 (0.67) | ASIC3PDPK1NOS3NOS1MEN1 | |
| SCHEMBL20390897 | 0.73 | ASIC3 (0.53) | ASIC3PDPK1DYRK1ANOS3NOS1 | |
| SCHEMBL29686168 | 0.73 | — | — | |
| SCHEMBL244187 | 0.73 | — | — | |
| SCHEMBL29601960 | 0.72 | ASIC3 (0.68) | ASIC3PDPK1NOS3NOS1MEN1 | |
| SCHEMBL1073895 | 0.72 | ASIC3 (0.68) | ASIC3PDPK1NOS3NOS1MEN1 | |
| SCHEMBL901899 | 0.72 | ASIC3 (0.57) | ASIC3PDPK1DYRK1ANOS3NOS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2459535-A1 | PYRIDINE AND PYRAZINE DERIVATIVES AS PROTEIN KINASE MODULATORS | Novartis AG (CH) | 2012-06-06 | — | — | EP | disclosed |
| EP-2441755-A1 | Pyridine- and isoquinoline-derivatives as Syk and JAK kinase inhibitors | Almirall, S.A. (ES) | 2012-04-18 | — | — | EP | disclosed |
| WO-2012041476-A1 | PYRIDINE AND ISOQUINOLINE DERIVATIVES AS SYK- AND JAK-KINASE INHIBITORS | ALMIRALL, S.A. (ES) | 2012-04-05 | — | — | WO | disclosed |
| WO-2011012661-A1 | PYRIDINE AND PYRAZINE DERIVATIVES AS PROTEIN KINASE MODULATORS | NOVARTIS AG (CH) | 2011-02-03 | — | — | WO | disclosed |