Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 4/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | BLM | P54132 | 2/20 | 0.46 |
| ▸ | HTR1A | P08908 | 1/20 | 0.46 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.46 |
| ▸ | CNR1 | P21554 | 1/20 | 0.46 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | ABCC8 | Q09428 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9018101 | 0.94 | EPHX2 (0.43) | EPHX2LMNACYP3A4CYP2C9CYP2C19 | |
| SCHEMBL9018170 | 0.93 | LMNA (0.46) | EPHX2LMNACYP3A4CYP2C9CYP2C19 | |
| SCHEMBL9018486 | 0.92 | LMNA (0.42) | EPHX2LMNACYP3A4CYP2C9CYP2C19 | |
| SCHEMBL9018253 | 0.92 | LMNA (0.44) | LMNACYP3A4CYP2C9CYP2C19MAPT | |
| SCHEMBL9018367 | 0.91 | LMNA (0.42) | EPHX2LMNACYP3A4CYP2C9CYP2C19 | |
| SCHEMBL9018188 | 0.91 | LMNA (0.42) | EPHX2LMNACYP3A4CYP2C9CYP2C19 | |
| SCHEMBL9018312 | 0.91 | EPHX2 (0.47) | EPHX2LMNACYP3A4CYP2C9CYP2C19 | |
| SCHEMBL7867832 | 0.90 | EPHX2 (0.43) | EPHX2LMNACYP3A4CYP2C9CYP2C19 | |
| SCHEMBL7870571 | 0.88 | EPHX2 (0.45) | EPHX2LMNACYP3A4CYP2C9CYP2C19 | |
| SCHEMBL9018314 | 0.88 | MAPT (0.49) | LMNACYP3A4CYP2C9CYP2C19MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0590520-B1 | Acylsulphonamido and sulphonamidopyridine-2-carboxylic acid esters, pyridine-n-oxides thereof, a process for their preparation and their use as medicaments | HOECHST AG (DE) | 1996-06-12 | — | — | EP | disclosed |
| EP-0590520-A1 | Acylsulphonamido and sulphonamidopyridine-2-carboxylic acid esters, pyridine-n-oxides thereof, a process for their preparation and their use as medicaments | HOECHST AKTIENGESELLSCHAFT (DE) | 1994-04-06 | — | — | EP | disclosed |