Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.48 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.47 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.47 |
| ▸ | CA12 | O43570 | 2/20 | 0.47 |
| ▸ | CA1 | P00915 | 2/20 | 0.47 |
| ▸ | CA2 | P00918 | 2/20 | 0.47 |
| ▸ | CA9 | Q16790 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 3/20 | 0.46 |
| ▸ | RAB9A | P51151 | 3/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.45 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.44 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9018181 | 1.00 | MAPT (0.54) | MAPTMEN1KMT2AEPHX2BCL2L1 | |
| SCHEMBL9018107 | 0.93 | MAPT (0.51) | MAPTMEN1KMT2AEPHX2BCL2L1 | |
| SCHEMBL9018340 | 0.93 | MAPT (0.51) | MAPTMEN1KMT2AEPHX2BCL2L1 | |
| SCHEMBL9018557 | 0.93 | MAPT (0.51) | MAPTMEN1KMT2AEPHX2BCL2L1 | |
| SCHEMBL9018324 | 0.92 | MAPT (0.54) | MAPTMEN1KMT2AEPHX2BCL2L1 | |
| SCHEMBL9018414 | 0.92 | MAPT (0.54) | MAPTMEN1KMT2AEPHX2BCL2L1 | |
| SCHEMBL9018029 | 0.91 | MEN1 (0.50) | MAPTMEN1KMT2ABCL2L1MCL1 | |
| SCHEMBL9018462 | 0.91 | MAPT (0.49) | MAPTMEN1KMT2AEPHX2BCL2L1 | |
| SCHEMBL9018061 | 0.91 | MAPT (0.49) | MAPTMEN1KMT2AEPHX2BCL2L1 | |
| SCHEMBL9018057 | 0.91 | KMT2A (0.58) | MAPTMEN1KMT2ALMNATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0590520-B1 | Acylsulphonamido and sulphonamidopyridine-2-carboxylic acid esters, pyridine-n-oxides thereof, a process for their preparation and their use as medicaments | HOECHST AG (DE) | 1996-06-12 | — | — | EP | disclosed |
| EP-0590520-A1 | Acylsulphonamido and sulphonamidopyridine-2-carboxylic acid esters, pyridine-n-oxides thereof, a process for their preparation and their use as medicaments | HOECHST AKTIENGESELLSCHAFT (DE) | 1994-04-06 | — | — | EP | disclosed |