Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | PPARA | Q07869 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.47 |
| ▸ | P4HTM | Q9NXG6 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.46 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.46 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.46 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.46 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.46 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.46 |
| ▸ | CA12 | O43570 | 1/20 | 0.46 |
| ▸ | CA1 | P00915 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9018232 | 0.97 | NPC1 (0.51) | MEN1KMT2AMAPTPPARASMN1; SMN2 | |
| SCHEMBL9018480 | 0.93 | MEN1 (0.47) | MEN1KMT2AMAPTPPARASMN1; SMN2 | |
| SCHEMBL9018251 | 0.92 | MAPT (0.49) | MEN1KMT2AMAPTPPARASMN1; SMN2 | |
| SCHEMBL9018179 | 0.91 | NPC1 (0.49) | SMN1; SMN2NPC1RAB9AP4HTMOPRM1 | |
| SCHEMBL9018181 | 0.91 | MAPT (0.54) | MEN1KMT2AMAPTSMN1; SMN2NPC1 | |
| SCHEMBL9018347 | 0.91 | EGFR (0.53) | MEN1KMT2AMAPTPPARASMN1; SMN2 | |
| SCHEMBL9018049 | 0.91 | MAPT (0.54) | MEN1KMT2AMAPTSMN1; SMN2NPC1 | |
| SCHEMBL9018057 | 0.91 | KMT2A (0.58) | MEN1KMT2AMAPTPPARASMN1; SMN2 | |
| SCHEMBL9018380 | 0.91 | MEN1 (0.46) | MEN1KMT2AMAPTPPARASMN1; SMN2 | |
| SCHEMBL9018274 | 0.91 | RAB9A (0.48) | MAPTPPARASMN1; SMN2NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0590520-B1 | Acylsulphonamido and sulphonamidopyridine-2-carboxylic acid esters, pyridine-n-oxides thereof, a process for their preparation and their use as medicaments | HOECHST AG (DE) | 1996-06-12 | — | — | EP | disclosed |
| EP-0590520-A1 | Acylsulphonamido and sulphonamidopyridine-2-carboxylic acid esters, pyridine-n-oxides thereof, a process for their preparation and their use as medicaments | HOECHST AKTIENGESELLSCHAFT (DE) | 1994-04-06 | — | — | EP | disclosed |