Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | CA12 | O43570 | 1/20 | 0.47 |
| ▸ | CA1 | P00915 | 1/20 | 0.47 |
| ▸ | CA9 | Q16790 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | HTR1A | P08908 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.47 |
| ▸ | CNR1 | P21554 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.47 |
| ▸ | BLM | P54132 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9018193 | 0.91 | LMNA (0.53) | LMNAKMT2ATSHRSMN1; SMN2BLM | |
| SCHEMBL9018095 | 0.88 | LMNA (0.47) | LMNAKMT2ACA12CA1CA9 | |
| SCHEMBL9018241 | 0.87 | LMNA (0.49) | LMNAKMT2ATSHRSMN1; SMN2BLM | |
| SCHEMBL9017983 | 0.87 | CA12 (0.46) | LMNAKMT2ACA12CA1CA9 | |
| SCHEMBL9018442 | 0.87 | LMNA (0.51) | LMNAKMT2ATSHRSMN1; SMN2BLM | |
| SCHEMBL9018273 | 0.87 | LMNA (0.51) | LMNAKMT2ATSHRSMN1; SMN2BLM | |
| SCHEMBL7867700 | 0.85 | LMNA (0.45) | LMNAKMT2ACA12CA1CA9 | |
| SCHEMBL9140466 | 0.85 | LMNA (0.51) | LMNAKMT2ACA12CA1CA9 | |
| SCHEMBL9018409 | 0.84 | MAPT (0.49) | LMNAKMT2ATSHRSMN1; SMN2CYP3A4 | |
| SCHEMBL7862846 | 0.84 | LMNA (0.47) | LMNAKMT2ACA12CA1CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0590520-B1 | Acylsulphonamido and sulphonamidopyridine-2-carboxylic acid esters, pyridine-n-oxides thereof, a process for their preparation and their use as medicaments | HOECHST AG (DE) | 1996-06-12 | — | — | EP | disclosed |
| EP-0590520-A1 | Acylsulphonamido and sulphonamidopyridine-2-carboxylic acid esters, pyridine-n-oxides thereof, a process for their preparation and their use as medicaments | HOECHST AKTIENGESELLSCHAFT (DE) | 1994-04-06 | — | — | EP | disclosed |