Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P4HTM | Q9NXG6 | 4/20 | 0.60 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | EGFR | P00533 | 2/20 | 0.45 |
| ▸ | GFER | P55789 | 1/20 | 0.44 |
| ▸ | MMP2 | P08253 | 3/20 | 0.43 |
| ▸ | MMP9 | P14780 | 2/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | MMP1 | P03956 | 1/20 | 0.42 |
| ▸ | MMP8 | P22894 | 1/20 | 0.42 |
| ▸ | MMP13 | P45452 | 1/20 | 0.42 |
| ▸ | CA12 | O43570 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.42 |
| ▸ | FLT1 | P17948 | 1/20 | 0.42 |
| ▸ | FLT4 | P35916 | 1/20 | 0.42 |
| ▸ | KDR | P35968 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9017985 | 0.92 | P4HTM (0.66) | P4HTMHSD17B10LMNAEGFRGFER | |
| SCHEMBL9018037 | 0.90 | KMT2A (0.53) | P4HTMHSD17B10LMNAALDH1A1MEN1 | |
| SCHEMBL9018456 | 0.89 | P4HTM (0.57) | P4HTMHSD17B10LMNAEGFRGFER | |
| SCHEMBL9018452 | 0.89 | MCL1 (0.55) | P4HTMMMP2MMP9MMP1MMP13 | |
| SCHEMBL9018334 | 0.88 | P4HTM (0.58) | P4HTMLMNAEGFRFLT1FLT4 | |
| SCHEMBL9018421 | 0.85 | P4HTM (0.66) | P4HTMHSD17B10EGFRGFERMMP2 | |
| SCHEMBL9018479 | 0.85 | EGFR (0.43) | P4HTMEGFRCA12CA9FLT1 | |
| SCHEMBL9018335 | 0.85 | P4HTM (0.60) | P4HTMHSD17B10LMNAEGFRGFER | |
| SCHEMBL9018202 | 0.85 | P4HTM (0.43) | P4HTMEGFRALDH1A1MEN1KMT2A | |
| SCHEMBL9018262 | 0.84 | SMN1; SMN2 (0.52) | P4HTMHSD17B10LMNAMMP2MMP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0590520-B1 | Acylsulphonamido and sulphonamidopyridine-2-carboxylic acid esters, pyridine-n-oxides thereof, a process for their preparation and their use as medicaments | HOECHST AG (DE) | 1996-06-12 | — | — | EP | disclosed |
| EP-0590520-A1 | Acylsulphonamido and sulphonamidopyridine-2-carboxylic acid esters, pyridine-n-oxides thereof, a process for their preparation and their use as medicaments | HOECHST AKTIENGESELLSCHAFT (DE) | 1994-04-06 | — | — | EP | disclosed |