Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 6/20 | 0.67 |
| ▸ | GPBAR1 | Q8TDU6 | 3/20 | 0.59 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.59 |
| ▸ | CYSLTR2 | Q9NS75 | 9/20 | 0.58 |
| ▸ | CYSLTR1 | Q9Y271 | 9/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.57 |
| ▸ | TP53 | P04637 | 1/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.57 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.57 |
| ▸ | TSHR | P16473 | 1/20 | 0.57 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.57 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.57 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | GMNN | O75496 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
| ▸ | HPGD | P15428 | 1/20 | 0.57 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10411470 | 0.99 | ALOX5 (0.66) | ALOX5GPBAR1HDAC6CYSLTR2CYSLTR1 | |
| SCHEMBL9498315 | 0.97 | ALOX5 (0.63) | ALOX5GPBAR1HDAC6CYSLTR2CYSLTR1 | |
| SCHEMBL8646511 | 0.93 | CYSLTR2 (0.63) | ALOX5GPBAR1HDAC6CYSLTR2CYSLTR1 | |
| SCHEMBL10410383 | 0.89 | CYSLTR2 (0.62) | ALOX5GPBAR1HDAC6CYSLTR2CYSLTR1 | |
| SCHEMBL10410457 | 0.89 | ALOX5 (0.62) | ALOX5GPBAR1CYSLTR2CYSLTR1MAPK1 | |
| SCHEMBL10411468 | 0.89 | ALOX5 (0.62) | ALOX5GPBAR1HDAC6CYSLTR2CYSLTR1 | |
| SCHEMBL10410421 | 0.89 | ALOX5 (0.61) | ALOX5GPBAR1HDAC6CYSLTR2CYSLTR1 | |
| SCHEMBL10410643 | 0.89 | GPBAR1 (0.64) | ALOX5GPBAR1HDAC6CYSLTR2CYSLTR1 | |
| SCHEMBL8715482 | 0.87 | CYSLTR2 (0.60) | ALOX5GPBAR1HDAC6CYSLTR2CYSLTR1 | |
| SCHEMBL9499746 | 0.86 | CYSLTR2 (0.59) | ALOX5GPBAR1CYSLTR2CYSLTR1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4929626-A | α-substituted 4-(quinolin-2-yl-methoxy)phenylacetic acids and esters and lipoxygenase inhibition therewith | BAYER AKTIENGESELLSCHAFT (DE) | 1990-05-29 | — | — | US | claimed |
| EP-0414019-B1 | Subsituted N-(quinolin-2-yl-methoxy)benzylsulfonylureas | BAYER AG (DE) | 1996-05-29 | — | — | EP | disclosed |
| EP-0339416-B1 | OPTIONALLY ALPHA-SUBSTITUTED 4-(QUINOLIN-2-YL-METHOXY)PHENYL ACETIC ACIDS AND ESTERS | BAYER AG (DE) | 1993-05-26 | — | — | EP | disclosed |
| US-5179106-A | SUBSTITUTED N-(QUINOLIN-2-YL-METHOXY) BENZYL-SULPHONYLUREA LEUKOTRIENE SYNTHESIS INHIBITORS | BAYER AKTIENGESELLSCHAFT (DE) | 1993-01-12 | — | — | US | disclosed |
| US-4929626-A | α-substituted 4-(quinolin-2-yl-methoxy)phenylacetic acids and esters and lipoxygenase inhibition therewith | BAYER AKTIENGESELLSCHAFT (DE) | 1990-05-29 | — | — | US | disclosed |
| EP-0339416-A1 | Optionally alpha-substituted 4-(quinolin-2-yl-methoxy)phenyl acetic acids and esters | BAYER AG (DE) | 1989-11-02 | — | — | EP | disclosed |