Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.42 |
| ▸ | XPO1 | O14980 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | CCR1 | P32246 | 2/20 | 0.39 |
| ▸ | AR | P10275 | 1/20 | 0.38 |
| ▸ | PARP1 | P09874 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 3/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 3/20 | 0.35 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17179178 | 0.82 | FAAH (0.42) | FAAHHDAC1HDAC2HDAC8HDAC6 | |
| SCHEMBL5365121 | 0.82 | FAAH (0.42) | FAAHHDAC1HDAC2HDAC8HDAC6 | |
| SCHEMBL28887382 | 0.82 | FAAH (0.42) | FAAHHDAC1HDAC2HDAC8HDAC6 | |
| SCHEMBL13010265 | 0.82 | PARP1 (0.54) | FAAHHDAC1HDAC2HDAC8HDAC6 | |
| SCHEMBL29518341 | 0.82 | CCR1 (0.63) | FAAHHDAC1HDAC2HDAC8HDAC6 | |
| SCHEMBL201143 | 0.82 | CCR1 (0.63) | FAAHHDAC1HDAC2HDAC8HDAC6 | |
| SCHEMBL31648790 | 0.80 | CCR1 (0.56) | ALDH1A1TDP1L3MBTL1CCR1PARP1 | |
| SCHEMBL8944345 | 0.80 | CCR1 (0.56) | ALDH1A1TDP1L3MBTL1CCR1PARP1 | |
| SCHEMBL14126759 | 0.79 | PDE10A (0.41) | FAAHHDAC1HDAC2HDAC8HDAC6 | |
| SCHEMBL14351724 | 0.79 | TAAR1 (0.47) | FAAHHDAC1HDAC2HDAC8HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0414019-B1 | Subsituted N-(quinolin-2-yl-methoxy)benzylsulfonylureas | BAYER AG (DE) | 1996-05-29 | — | — | EP | disclosed |
| US-5179106-A | SUBSTITUTED N-(QUINOLIN-2-YL-METHOXY) BENZYL-SULPHONYLUREA LEUKOTRIENE SYNTHESIS INHIBITORS | BAYER AKTIENGESELLSCHAFT (DE) | 1993-01-12 | — | — | US | disclosed |
| US-5045547-A | Leukotriene-inhibiting substituted (quinolin-2-yl-methoxy)phenyl-N,N'-sulphonylureas and use thereas | BAYER AKTIENGESELLSCHAFT (DE) | 1991-09-03 | — | — | US | disclosed |
| EP-0414019-A2 | Subsituted N-(quinolin-2-yl-methoxy)benzylsulfonylureas | BAYER AG (DE) | 1991-02-27 | — | — | EP | disclosed |
| CN-1045778-A | (quinolin-2-ylmethoxy) phenyl-N that replaces, N '-sulfonylurea, its preparation method and the application in medicine thereof | BAYER AG (DE) | 1990-10-03 | — | — | CN | disclosed |
| EP-0387610-A2 | Substituted (quinolin-2-yl methoxy)phenyl-N,N'-sulphonyl ureas, processes for their preparation and their use in medicines | BAYER AG (DE) | 1990-09-19 | — | — | EP | disclosed |