Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KARS1 | Q15046 | 12/20 | 0.71 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.44 |
| ▸ | JAK2 | O60674 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | SYK | P43405 | 2/20 | 0.40 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.39 |
| ▸ | ABL1 | P00519 | 1/20 | 0.39 |
| ▸ | LCK | P06239 | 1/20 | 0.39 |
| ▸ | FYN | P06241 | 1/20 | 0.39 |
| ▸ | IGF1R | P08069 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL902700 | 0.88 | KARS1 (0.54) | KARS1NR3C2SYK | |
| SCHEMBL901879 | 0.84 | KARS1 (0.71) | KARS1JAK2RAB9AMEN1NPC1 | |
| SCHEMBL902772 | 0.83 | KARS1 (1.00) | KARS1RAB9AMEN1NPC1KMT2A | |
| SCHEMBL12469132 | 0.83 | KARS1 (0.72) | KARS1NR3C2JAK2RAB9AMEN1 | |
| SCHEMBL1704304 | 0.83 | KARS1 (0.72) | KARS1JAK2RAB9AMEN1NPC1 | |
| SCHEMBL902781 | 0.81 | KARS1 (1.00) | KARS1RAB9AMEN1NPC1KMT2A | |
| SCHEMBL901655 | 0.80 | KARS1 (0.70) | KARS1JAK2RAB9AMEN1NPC1 | |
| SCHEMBL902758 | 0.78 | KARS1 (0.64) | KARS1JAK2RAB9AMEN1NPC1 | |
| SCHEMBL10268299 | 0.76 | KARS1 (0.70) | KARS1JAK2RAB9AMEN1NPC1 | |
| SCHEMBL902728 | 0.75 | KARS1 (1.00) | KARS1RAB9AMEN1NPC1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2441755-A1 | Pyridine- and isoquinoline-derivatives as Syk and JAK kinase inhibitors | Almirall, S.A. (ES) | 2012-04-18 | — | — | EP | disclosed |
| WO-2012041476-A1 | PYRIDINE AND ISOQUINOLINE DERIVATIVES AS SYK- AND JAK-KINASE INHIBITORS | ALMIRALL, S.A. (ES) | 2012-04-05 | — | — | WO | disclosed |