Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 2/20 | 0.41 |
| ▸ | CA9 | Q16790 | 2/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | STAT3 | P40763 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | DHODH | Q02127 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | VDR | P11473 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | PSMD10 | O75832 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9019157 | 1.00 | CA12 (0.41) | CA12CA9CA1STAT3ALDH1A1 | |
| SCHEMBL28796788 | 0.92 | ALDH1A1 (0.40) | CA12CA9CA1STAT3ALDH1A1 | |
| SCHEMBL21458960 | 0.90 | CA12 (0.40) | CA12CA9CA1STAT3ALDH1A1 | |
| SCHEMBL23611469 | 0.89 | ALDH1A1 (0.40) | CA12CA9CA1STAT3ALDH1A1 | |
| SCHEMBL26613614 | 0.89 | STAT3 (0.38) | CA12CA9CA1STAT3ALDH1A1 | |
| SCHEMBL9019129 | 0.87 | CA12 (0.41) | CA12CA9CA1STAT3ALDH1A1 | |
| SCHEMBL9019172 | 0.87 | CA12 (0.41) | CA12CA9CA1STAT3ALDH1A1 | |
| SCHEMBL9019135 | 0.87 | CA12 (0.41) | CA12CA9CA1STAT3ALDH1A1 | |
| SCHEMBL3293612 | 0.85 | STAT3 (0.41) | CA12CA9CA1STAT3ALDH1A1 | |
| SCHEMBL9019023 | 0.84 | CA12 (0.40) | CA12CA9CA1STAT3ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0434960-B1 | Chiral 1,5-diiodo-2-methoxy or benzyloxy intermediates | PHARMACIA SPA (IT) | 1996-09-18 | — | — | EP | disclosed |
| US-5304687-A | 1-alkoxy-2,2*-diiodo-diethyl ether which reacts with doxorubicin to yield anthrocycline antibiotics | FARMITALIA CARLO ERBA S.R.L. (IT) | 1994-04-19 | — | — | US | disclosed |
| EP-0434960-A1 | Chiral 1,5-diiodo-2-methoxy or benzyloxy intermediates | PHARMACIA S.p.A. (IT) | 1991-07-03 | — | — | EP | disclosed |
| WO-1991009046-A1 | MORPHOLINYL DERIVATIVES OF DOXORUBICIN AND PROCESS FOR THEIR PREPARATION | FARMITALIA CARLO ERBA S.R.L. (IT) | 1991-06-27 | — | — | WO | disclosed |