⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL350816 | 0.84 | — | — | |
| SCHEMBL149393 | 0.81 | — | — | |
| SCHEMBL2440247 | 0.79 | FOLH1 (0.71) | — | |
| SCHEMBL2142956 | 0.78 | — | — | |
| Ammonia Solution, Strong SCHEMBL16760976 | 0.78 | — | — | |
| SCHEMBL9418943 | 0.78 | SLC1A1 (0.70) | — | |
| SCHEMBL7591996 | 0.78 | LMNA (0.52) | — | |
| SCHEMBL28070281 | 0.77 | — | — | |
| SCHEMBL9582293 | 0.74 | — | — | |
| SCHEMBL8499052 | 0.74 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3842074-A1 | PROTEIN-DRUG CONJUGATES | Philogen S.p.A. (IT) | 2021-06-30 | — | — | EP | disclosed |
| US-10344079-B2 | Methods of treating a neoplastic disease | PHILOGEN S.P.A. (IT) | 2019-07-09 | — | — | US | disclosed |
| US-9963540-B2 | Densely functionalized polymers derived from baylis-hillman adducts | THE UNIVERSITY OF AKRON (US) | 2018-05-08 | — | — | US | disclosed |
| EP-2988784-A1 | ANTIBODY-DRUG CONJUGATES | Philogen S.p.A. (IT) | 2016-03-02 | — | — | EP | disclosed |
| US-20160039920-A1 | Antibody-Drug Conjugates | PHILOCHEM AG (CH) | 2016-02-11 | — | — | US | disclosed |
| US-9198979-B2 | Thiazolidine linker for the conjugation of drugs to antibodies | PHILOGEN S.P.A. (IT) | 2015-12-01 | — | — | US | disclosed |
| WO-2014174105-A1 | ANTIBODY-DRUG CONJUGATES | PHILOCHEM AG (CH) | 2014-10-30 | — | — | WO | disclosed |
| US-20130309257-A1 | Thiazolidine Linker for the Conjugation of Drugs to Antibodies | PHILOGEN S.P.A. (IT) | 2013-11-21 | — | — | US | disclosed |
| EP-2621535-A1 | THIAZOLIDINE LINKER FOR THE CONJUGATION OF DRUGS TO ANTIBODIES | Philogen S.p.A. (IT) | 2013-08-07 | — | — | EP | disclosed |
| WO-2012041451-A1 | THIAZOLIDINE LINKER FOR THE CONJUGATION OF DRUGS TO ANTIBODIES | PHILOGEN S.P.A. (IT) | 2012-04-05 | — | — | WO | disclosed |