Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.50 |
| ▸ | RAB9A | P51151 | 3/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | MAOA | P21397 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | XBP1 | P17861 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4844145 | 0.77 | CYP3A4 (0.46) | SMN1; SMN2KMT2AKDM4EUSP2CYP3A4 | |
| SCHEMBL8546247 | 0.76 | CYP3A4 (0.55) | SMN1; SMN2KMT2AUSP2CYP3A4CYP2D6 | |
| SCHEMBL1500114 | 0.75 | CYP3A4 (0.47) | NPC1RAB9ASMN1; SMN2KMT2AUSP2 | |
| SCHEMBL6560050 | 0.73 | KMT2A (0.50) | KMT2AMAPTTP53KDM4EUSP2 | |
| SCHEMBL9905988 | 0.70 | KMT2A (0.68) | NPC1RAB9ASMN1; SMN2KMT2AMAPT | |
| SCHEMBL13186069 | 0.70 | KMT2A (0.55) | NPC1SMN1; SMN2KMT2AUSP2CYP3A4 | |
| SCHEMBL28320490 | 0.70 | CYP3A4 (0.49) | SMN1; SMN2KMT2AUSP2CYP3A4CYP2D6 | |
| SCHEMBL30506419 | 0.70 | CYP3A4 (0.67) | SMN1; SMN2KMT2AMAPTMEN1TP53 | |
| SCHEMBL2874467 | 0.70 | CYP3A4 (0.67) | SMN1; SMN2KMT2AMAPTMEN1TP53 | |
| SCHEMBL9559998 | 0.69 | CYP3A4 (0.47) | SMN1; SMN2KMT2AMAPTMEN1USP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0450588-B1 | Substituted 3-thia- or 3-oxa-alkyl flavones, process for their preparation, their application and drugs based on these compounds as well as intermediates | HOECHST AG (DE) | 1996-02-28 | — | — | EP | disclosed |
| US-5173498-A | For treating arteriosclerosis or hypercholesterolemia | HOECHST AKTIENGESELLSCHAFT (DE) | 1992-12-22 | — | — | US | disclosed |
| EP-0450588-A1 | Substituted 3-thia- or 3-oxa-alkyl flavones, process for their preparation, their application and drugs based on these compounds as well as intermediates | HOECHST AKTIENGESELLSCHAFT (DE) | 1991-10-09 | — | — | EP | disclosed |