Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 2/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | HMGCR | P04035 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | HTR1A | P08908 | 1/20 | 0.43 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.43 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.43 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | EBP | Q15125 | 1/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8546247 | 0.86 | CYP3A4 (0.55) | CYP3A4USP2MAPK1SMN1; SMN2HMGCR | |
| SCHEMBL6507929 | 0.84 | SMN1; SMN2 (0.53) | CYP3A4USP2MAPK1SMN1; SMN2ALDH1A1 | |
| SCHEMBL4843393 | 0.81 | TP53 (0.56) | CYP3A4USP2SMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL28320490 | 0.80 | CYP3A4 (0.49) | CYP3A4USP2MAPK1SMN1; SMN2HMGCR | |
| SCHEMBL2874467 | 0.80 | CYP3A4 (0.67) | CYP3A4USP2MAPK1SMN1; SMN2HMGCR | |
| SCHEMBL30506419 | 0.80 | CYP3A4 (0.67) | CYP3A4USP2MAPK1SMN1; SMN2HMGCR | |
| SCHEMBL9559998 | 0.79 | CYP3A4 (0.47) | CYP3A4USP2MAPK1SMN1; SMN2HMGCR | |
| SCHEMBL1500114 | 0.79 | CYP3A4 (0.47) | CYP3A4USP2MAPK1SMN1; SMN2HMGCR | |
| SCHEMBL4407605 | 0.77 | PTPN1 (0.46) | CYP3A4USP2MAPK1SMN1; SMN2ALDH1A1 | |
| SCHEMBL9019336 | 0.77 | NPC1 (0.50) | CYP3A4USP2SMN1; SMN2CYP2D6CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7423030-B2 | 1-amino-phthalazine derivatives, the preparation and the therapeutic use thereof | SANOFI-AVENTIS (FR) | 2008-09-09 | — | — | US | disclosed |
| US-20070099895-A1 | 1-AMINO-PHTHALAZINE DERIVATIVES, THE PREPARATION AND THE THERAPEUTIC USE THEREOF | SANOFI-AVENTIS (FR) | 2007-05-03 | — | — | US | disclosed |
| CN-1953972-A | 1-amino-phthalazine derivatives, their preparation and their therapeutic use | SANOFI AVENTIS (FR) | 2007-04-25 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070099895-A1 | 1-AMINO-PHTHALAZINE DERIVATIVES, THE PREPARATION AND THE THERAPEUTIC USE THEREOF | CYP11B2, CYP11B1, GOT2 | CYP3A4 562/4885USP2 3551/4885MAPK1 2850/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.