SCHEMBL9019501

SCHEMBL9019501

CCCCCC(=O)NC1CCC(O)CC1

nearest known ligand 0.71

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GNAI3 P08754 1/20 0.64
GNAO1 P09471 1/20 0.64
GNAI1 P63096 1/20 0.64
MEN1 O00255 1/20 0.60
ALDH1A1 P00352 1/20 0.60
MAPT P10636 1/20 0.60
HPGD P15428 1/20 0.60
KMT2A Q03164 1/20 0.60
SMN1; SMN2 Q16637 1/20 0.58
CNR2 P34972 9/20 0.57
CNR1 P21554 8/20 0.57
TRPV1 Q8NER1 6/20 0.57
HDAC3 O15379 1/20 0.50
HDAC1 Q13547 1/20 0.50
HDAC2 Q92769 1/20 0.50
HDAC10 Q969S8 1/20 0.50
HDAC11 Q96DB2 1/20 0.50
HDAC8 Q9BY41 1/20 0.50
HDAC6 Q9UBN7 1/20 0.50
NCOR2 Q9Y618 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9019502 1.00 GNAI3 (0.64) GNAI3GNAO1GNAI1MEN1ALDH1A1
SCHEMBL3551415 0.93 GNAI3 (0.72) GNAI3GNAO1GNAI1MEN1ALDH1A1
SCHEMBL11571826 0.91 GNAI3 (0.75) GNAI3GNAO1GNAI1MEN1ALDH1A1
Hexadecanoic Acid Cyclopropylamide SCHEMBL1456457 0.91 GNAI3 (0.75) GNAI3GNAO1GNAI1MEN1ALDH1A1
SCHEMBL1457137 0.91 GNAI3 (0.75) GNAI3GNAO1GNAI1MEN1ALDH1A1
SCHEMBL1234276 0.91 GNAI3 (0.75) GNAI3GNAO1GNAI1MEN1ALDH1A1
SCHEMBL28340804 0.91 GNAI3 (0.75) GNAI3GNAO1GNAI1MEN1ALDH1A1
SCHEMBL8361102 0.91 GNAI3 (0.75) GNAI3GNAO1GNAI1MEN1ALDH1A1
SCHEMBL13573015 0.87 EPHX2 (0.54) GNAI3GNAO1GNAI1MEN1ALDH1A1
SCHEMBL11822035 0.87 EPHX2 (0.54) GNAI3GNAO1GNAI1MEN1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0515420-B1 NITRIC ACID ESTERS OF CYCLOHEXANOL DERIVATIVES BOEHRINGER MANNHEIM GMBH (DE) 1996-06-12 EP disclosed
US-5411989-A Cardiovascular disorders BOEHRINGER MANNHEIM, GMBH (DE) 1995-05-02 US disclosed
EP-0515420-A1 NITRIC ACID ESTERS OF CYCLOHEXANOL DERIVATIVES. BOEHRINGER MANNHEIM GMBH (DE) 1992-12-02 EP disclosed
WO-1991012230-A1 NITRIC ACID ESTERS OF CYCLOHEXANOL DERIVATIVES BOEHRINGER MANNHEIM GMBH (DE) 1991-08-22 WO disclosed