Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.51 |
| ▸ | MEN1 | O00255 | 3/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | NPC1 | O15118 | 2/20 | 0.51 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.51 |
| ▸ | RAB9A | P51151 | 2/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 5/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | QDPR | P09417 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | CNR1 | P21554 | 1/20 | 0.44 |
| ▸ | CASP3 | P42574 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5959136 | 0.85 | ALDH1A1 (0.57) | ALDH1A1SMN1; SMN2MEN1KMT2ANPC1 | |
| SCHEMBL2241959 | 0.85 | ALDH1A1 (0.67) | ALDH1A1SMN1; SMN2MEN1KMT2ANPC1 | |
| SCHEMBL4864624 | 0.84 | ALDH1A1 (0.52) | ALDH1A1SMN1; SMN2MEN1KMT2ANPC1 | |
| SCHEMBL16113804 | 0.84 | ALDH1A1 (0.52) | ALDH1A1SMN1; SMN2MEN1KMT2ANPC1 | |
| SCHEMBL4947674 | 0.83 | ALDH1A1 (0.50) | ALDH1A1SMN1; SMN2MEN1KMT2ANPC1 | |
| SCHEMBL3993976 | 0.83 | ALDH1A1 (0.51) | ALDH1A1SMN1; SMN2MEN1KMT2ANPC1 | |
| SCHEMBL16496703 | 0.83 | ALDH1A1 (0.52) | ALDH1A1SMN1; SMN2MEN1KMT2ANPC1 | |
| SCHEMBL5373499 | 0.83 | MAPT (0.55) | ALDH1A1SMN1; SMN2MEN1KMT2ANPC1 | |
| SCHEMBL28811687 | 0.82 | ALDH1A1 (0.63) | ALDH1A1SMN1; SMN2MEN1KMT2ANPC1 | |
| SCHEMBL902871 | 0.81 | PDK4 (0.56) | CNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2489663-A1 | Compounds as syk kinase inhibitors | Almirall, S.A. (ES) | 2012-08-22 | — | — | EP | disclosed |
| EP-2441755-A1 | Pyridine- and isoquinoline-derivatives as Syk and JAK kinase inhibitors | Almirall, S.A. (ES) | 2012-04-18 | — | — | EP | disclosed |
| WO-2012041476-A1 | PYRIDINE AND ISOQUINOLINE DERIVATIVES AS SYK- AND JAK-KINASE INHIBITORS | ALMIRALL, S.A. (ES) | 2012-04-05 | — | — | WO | disclosed |
| CN-1906163-A | 4-phenylpiperidine derivatives as renin inhibitors | NOVARTIS AG (CH) | 2007-01-31 | — | — | CN | disclosed |