Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 8/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 4/20 | 0.38 |
| ▸ | DRD3 | P35462 | 3/20 | 0.38 |
| ▸ | DRD4 | P21917 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10643997 | 0.87 | HTT (0.43) | HTR1AHTTDRD2DRD3DRD4 | |
| SCHEMBL9019837 | 0.82 | HTR1A (0.39) | HTR1AHTTDRD2DRD3DRD4 | |
| SCHEMBL9189350 | 0.80 | HTR1A (0.43) | HTR1AHTTDRD2DRD3DRD4 | |
| SCHEMBL8634507 | 0.80 | HTR1A (0.43) | HTR1AHTTDRD2DRD3DRD4 | |
| SCHEMBL9019746 | 0.77 | HTR1A (0.41) | HTR1AHTTDRD2DRD3DRD4 | |
| SCHEMBL9187440 | 0.77 | HTT (0.42) | HTR1AHTTDRD2DRD3DRD4 | |
| SCHEMBL9185072 | 0.76 | HTR1A (0.41) | HTR1AHTTDRD2DRD3DRD4 | |
| Hydrochloric Acid SCHEMBL9359457 | 0.76 | HTR1A (0.41) | HTR1AHTTDRD2DRD3DRD4 | |
| Hydrochloric Acid SCHEMBL9359991 | 0.75 | HTR1A (0.40) | HTR1AHTTDRD2DRD3DRD4 | |
| SCHEMBL9019753 | 0.75 | HTR1A (0.40) | HTR1AHTTDRD2DRD3DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0455510-B1 | Use of 5-HT1A receptor agonist compounds for inhibiting gastric acid secretion | LILLY CO ELI (US) | 1996-11-27 | — | — | EP | disclosed |
| EP-0385658-B1 | Ring-substituted 2-amino 1,2,3,4-tetra-hydronaphthalenes and 3-aminochromanes | LILLY CO ELI (US) | 1994-12-28 | — | — | EP | disclosed |
| EP-0455510-A2 | Use of 5-HT1A receptor agonist compounds for inhibiting gastric acid secretion | ELI LILLY AND COMPANY (US) | 1991-11-06 | — | — | EP | disclosed |
| EP-0385658-A1 | Ring-substituted 2-amino 1,2,3,4-tetra-hydronaphthalenes and 3-aminochromanes | ELI LILLY AND COMPANY (US) | 1990-09-05 | — | — | EP | disclosed |