Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBXA2R | P21731 | 15/20 | 0.61 |
| ▸ | TBXAS1 | P24557 | 8/20 | 0.52 |
| ▸ | PDE2A | O00408 | 5/20 | 0.51 |
| ▸ | PTGDR | Q13258 | 4/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9019680 | 0.93 | TBXA2R (0.72) | TBXA2RTBXAS1PDE2APTGDRMEN1 | |
| SCHEMBL9019718 | 0.91 | TBXA2R (0.69) | TBXA2RTBXAS1PDE2APTGDRMEN1 | |
| SCHEMBL9019685 | 0.88 | TBXA2R (0.57) | TBXA2RTBXAS1PDE2APTGDRMEN1 | |
| SCHEMBL9019690 | 0.88 | TBXA2R (0.56) | TBXA2RTBXAS1PDE2APTGDRMEN1 | |
| SCHEMBL9019689 | 0.84 | TBXA2R (0.71) | TBXA2RTBXAS1PDE2APTGDRMEN1 | |
| SCHEMBL9019738 | 0.83 | TBXA2R (0.65) | TBXA2RTBXAS1PDE2APTGDR | |
| SCHEMBL9019681 | 0.83 | TBXA2R (0.57) | TBXA2RTBXAS1PDE2APTGDRMEN1 | |
| SCHEMBL9019688 | 0.82 | TBXA2R (0.74) | TBXA2RTBXAS1PDE2APTGDRMEN1 | |
| SCHEMBL9019721 | 0.80 | TBXA2R (0.49) | TBXA2RTBXAS1PDE2APTGDR | |
| SCHEMBL9019684 | 0.80 | TBXA2R (0.72) | TBXA2RPDE2APTGDRMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0496237-B1 | N-imidazolyl derivatives of substituted tetrahydrocarbazole and cyclohept[b]indole | PHARMACIA SPA (IT) | 1996-02-14 | — | — | EP | claimed |
| EP-0496237-A2 | N-imidazolyl derivatives of substituted tetrahydrocarbazole and cyclohept[b]indole | PHARMACIA S.p.A. (IT) | 1992-07-29 | — | — | EP | claimed |
| EP-0496237-B1 | N-imidazolyl derivatives of substituted tetrahydrocarbazole and cyclohept[b]indole | PHARMACIA SPA (IT) | 1996-02-14 | — | — | EP | disclosed |
| US-5238953-A | Thromboxane a2 antagonist | FARMITALIA CARLO ERBA S.R.L. (IT) | 1993-08-24 | — | — | US | disclosed |
| EP-0496237-A2 | N-imidazolyl derivatives of substituted tetrahydrocarbazole and cyclohept[b]indole | PHARMACIA S.p.A. (IT) | 1992-07-29 | — | — | EP | disclosed |