Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.68 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.68 |
| ▸ | HBB | P68871 | 2/20 | 0.67 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.67 |
| ▸ | PNP | P00491 | 7/20 | 0.66 |
| ▸ | TSHR | P16473 | 2/20 | 0.66 |
| ▸ | BLM | P54132 | 2/20 | 0.66 |
| ▸ | USP2 | O75604 | 1/20 | 0.66 |
| ▸ | EDNRA | P25101 | 1/20 | 0.66 |
| ▸ | HTR2A | P28223 | 1/20 | 0.66 |
| ▸ | RECQL | P46063 | 1/20 | 0.66 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.66 |
| ▸ | HPRT1 | P00492 | 6/20 | 0.61 |
| ▸ | POLG | P54098 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.53 |
| ▸ | VCP | P55072 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12671989 | 0.96 | MEN1 (0.66) | MEN1KMT2AHBBMAPK1PNP | |
| SCHEMBL12671790 | 0.91 | MEN1 (0.60) | MEN1KMT2AHBBMAPK1PNP | |
| SCHEMBL12636643 | 0.90 | MEN1 (0.61) | MEN1KMT2AHBBMAPK1PNP | |
| SCHEMBL8445568 | 0.90 | MEN1 (0.73) | MEN1KMT2AHBBMAPK1PNP | |
| SCHEMBL1884292 | 0.89 | PNP (0.71) | MEN1KMT2AHBBMAPK1PNP | |
| SCHEMBL1882478 | 0.89 | PNP (0.71) | MEN1KMT2AHBBMAPK1PNP | |
| SCHEMBL14421640 | 0.88 | PNP (0.74) | MEN1KMT2AHBBMAPK1PNP | |
| SCHEMBL8842958 | 0.88 | PNP (0.69) | MEN1KMT2AHBBMAPK1PNP | |
| SCHEMBL1178765 | 0.87 | PNP (0.61) | MEN1KMT2AHBBMAPK1PNP | |
| SCHEMBL14501075 | 0.86 | PNP (0.73) | MEN1KMT2AHBBMAPK1PNP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0351215-B1 | Ester of 9-(2-hydroxyethoxymethyl) guanine | WELLCOME FOUND (GB) | 1996-06-19 | — | — | EP | claimed |
| US-5079252-A | Valeryl ester of acyclovir improves bioavailability of acylclovir, viricides, treatment of herpes | BUROUGHS WELCOME CO. (US) | 1992-01-07 | — | — | US | claimed |
| JP-2073086-A | — | — | None | — | — | JP | disclosed |
| EP-0351215-B1 | Ester of 9-(2-hydroxyethoxymethyl) guanine | WELLCOME FOUND (GB) | 1996-06-19 | — | — | EP | disclosed |
| US-5079252-A | Valeryl ester of acyclovir improves bioavailability of acylclovir, viricides, treatment of herpes | BUROUGHS WELCOME CO. (US) | 1992-01-07 | — | — | US | disclosed |
| JP-H0273086-A | THERAPEUTIC COMPOUND | WELLCOME FOUND LTD:THE | 1990-03-13 | — | — | JP | disclosed |
| EP-0351215-A2 | Ester of 9-(2-hydroxyethoxymethyl) guanine | THE WELLCOME FOUNDATION LIMITED (GB) | 1990-01-17 | — | — | EP | disclosed |