Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM3 | P20309 | 5/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | CHRM1 | P11229 | 4/20 | 0.37 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.37 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.37 |
| ▸ | HTR3B | O95264 | 1/20 | 0.37 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.37 |
| ▸ | HTR3A | P46098 | 1/20 | 0.37 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.37 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.36 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.36 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9020198 | 1.00 | CHRM3 (0.39) | CHRM3SLC6A2SLC6A3GAACHRM1 | |
| Hydrochloric Acid SCHEMBL9020377 | 0.99 | CHRM3 (0.38) | CHRM3SLC6A2SLC6A3GAACHRM1 | |
| Hydrochloric Acid SCHEMBL9020373 | 0.99 | CHRM3 (0.38) | CHRM3SLC6A2SLC6A3GAACHRM1 | |
| SCHEMBL9020386 | 0.83 | CHRM1 (0.41) | CHRM3SLC6A2SLC6A3CHRM1CHRM2 | |
| SCHEMBL9020389 | 0.83 | CHRM1 (0.41) | CHRM3SLC6A2SLC6A3CHRM1CHRM2 | |
| Hydrochloric Acid SCHEMBL9019999 | 0.82 | CHRM1 (0.40) | CHRM3SLC6A2SLC6A3CHRM1CHRM2 | |
| Hydrochloric Acid SCHEMBL9020003 | 0.82 | CHRM1 (0.40) | CHRM3SLC6A2SLC6A3CHRM1CHRM2 | |
| SCHEMBL10991884 | 0.79 | HRH4 (0.51) | KMT2AKDM4E | |
| SCHEMBL9020108 | 0.79 | HTR3A (0.44) | CHRM3GAACHRM1CHRM2HTR3E | |
| Hydrochloric Acid SCHEMBL9429125 | 0.78 | HTR3A (0.43) | CHRM3GAACHRM1CHRM2HTR3E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0498331-B1 | N-(aryloxyalkyl)heteroaryl-8-azabicyclo(3.2.1)octanes, intermediates and a process for the preparation thereof and their use as medicaments | HOECHST ROUSSEL PHARMA (US) | 1996-05-22 | — | — | EP | disclosed |
| US-5340936-A | Antipsychotic agents | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1994-08-23 | — | — | US | disclosed |
| US-5234931-A | Anxiolytic agents; antdepressants; schizophrenia; drug abuse; medical diagnosis | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1993-08-10 | — | — | US | disclosed |
| EP-0498331-A1 | N-(aryloxyalkyl)heteroaryl-8-azabicyclo(3.2.1)octanes, intermediates and a process for the preparation thereof and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1992-08-12 | — | — | EP | disclosed |