SCHEMBL9020754

SCHEMBL9020754

COC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(=O)O)NC(C)=O

nearest known ligand 0.62

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.62
THRB P10828 1/20 0.62
CYP2C9 P11712 1/20 0.62
CYP2C19 P33261 1/20 0.62
HSD17B10 Q99714 1/20 0.62
ATM Q13315 1/20 0.56
TACR1 P25103 1/20 0.55
POLB P06746 1/20 0.54
CTSS P25774 1/20 0.53
CTSK P43235 1/20 0.53
PAM P19021 1/20 0.53
GNPAT O15228 1/20 0.53
BIRC2 Q13490 1/20 0.53
LMNA P02545 1/20 0.52
GLA P06280 1/20 0.52
TSHR P16473 1/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16668525 1.00 ALDH1A1 (0.62) ALDH1A1THRBCYP2C9CYP2C19HSD17B10
SCHEMBL27488362 0.92 ALDH1A1 (0.68) ALDH1A1THRBCYP2C9CYP2C19HSD17B10
SCHEMBL3734223 0.92 ALDH1A1 (0.68) ALDH1A1THRBCYP2C9CYP2C19HSD17B10
SCHEMBL9020942 0.91 ALDH1A1 (0.61) ALDH1A1THRBCYP2C9CYP2C19HSD17B10
SCHEMBL16667994 0.91 ALDH1A1 (0.61) ALDH1A1THRBCYP2C9CYP2C19HSD17B10
SCHEMBL10791119 0.91 ALDH1A1 (0.64) ALDH1A1THRBCYP2C9CYP2C19HSD17B10
SCHEMBL803579 0.89 ATM (0.68) ALDH1A1THRBCYP2C9CYP2C19HSD17B10
SCHEMBL1884230 0.89 ATM (0.68) ALDH1A1THRBCYP2C9CYP2C19HSD17B10
SCHEMBL1879654 0.89 ATM (0.68) ALDH1A1THRBCYP2C9CYP2C19HSD17B10
SCHEMBL10915929 0.89 ALDH1A1 (0.58) ALDH1A1THRBCYP2C9CYP2C19HSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0478729-B1 PROCESS FOR MANUFACTURING ASPARTAME FROM A DIKETOPIPERAZINE AND NOVEL INTERMEDIATES AND DERIVATIVES THEREFOR NUTRASWEET CO (US) 1996-08-21 EP disclosed
EP-0478729-A4 PROCESS FOR MANUFACTURING ASPARTAME FROM A DIKETOPIPERAZINE AND NOVEL INTERMEDIATES AND DERIVATIVES THEREFOR 1993-06-16 EP disclosed
US-5144073-A Decyclization of diketopiperazine intermediates EASTMAN CHEMICAL COMPANY 1992-09-01 US disclosed
US-5144073-A Decyclization of diketopiperazine intermediates EASTMAN CHEMICAL COMPANY 1992-09-01 US disclosed
EP-0478729-A1 PROCESS FOR MANUFACTURING ASPARTAME FROM A DIKETOPIPERAZINE AND NOVEL INTERMEDIATES AND DERIVATIVES THEREFOR. NUTRASWEET CO (US) 1992-04-08 EP disclosed
WO-1991014378-A1 PROCESS FOR MANUFACTURING ASPARTAME FROM A DIKETOPIPERAZINE AND NOVEL INTERMEDIATES AND DERIVATIVES THEREFOR THE NUTRASWEET COMPANY (US) 1991-10-03 WO disclosed