Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KARS1 | Q15046 | 13/20 | 0.70 |
| ▸ | DYRK1A | Q13627 | 5/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | RAF1 | P04049 | 1/20 | 0.39 |
| ▸ | BRAF | P15056 | 1/20 | 0.39 |
| ▸ | GSK3B | P49841 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL901978 | 0.94 | KARS1 (0.65) | KARS1DYRK1AMEN1KMT2ARAF1 | |
| SCHEMBL901804 | 0.93 | KARS1 (0.68) | KARS1DYRK1AMEN1KMT2ARAF1 | |
| SCHEMBL901973 | 0.93 | KARS1 (0.69) | KARS1DYRK1A | |
| SCHEMBL902033 | 0.93 | KARS1 (0.72) | KARS1DYRK1AMEN1KMT2ARAF1 | |
| SCHEMBL901421 | 0.91 | KARS1 (0.82) | KARS1DYRK1A | |
| SCHEMBL901833 | 0.91 | KARS1 (0.72) | KARS1DYRK1ARAF1BRAF | |
| SCHEMBL901656 | 0.90 | KARS1 (0.63) | KARS1DYRK1AMEN1KMT2A | |
| SCHEMBL901379 | 0.90 | KARS1 (0.64) | KARS1DYRK1A | |
| SCHEMBL901791 | 0.89 | KARS1 (0.81) | KARS1DYRK1ARAF1BRAFGSK3B | |
| SCHEMBL902036 | 0.88 | KARS1 (0.81) | KARS1DYRK1AMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2441755-A1 | Pyridine- and isoquinoline-derivatives as Syk and JAK kinase inhibitors | Almirall, S.A. (ES) | 2012-04-18 | — | — | EP | disclosed |
| WO-2012041476-A1 | PYRIDINE AND ISOQUINOLINE DERIVATIVES AS SYK- AND JAK-KINASE INHIBITORS | ALMIRALL, S.A. (ES) | 2012-04-05 | — | — | WO | disclosed |