SCHEMBL9022160

SCHEMBL9022160

C[C@]12CC[C@H]3[C@@H](CC[C@H]4N(c5ccccc5)C(=O)CC[C@]34C)[C@@H]1CC[C@@H]2C(=O)N(N)c1ccccc1

nearest known ligand 0.55

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
SRD5A2 P31213 7/20 0.52
SRD5A1 P18405 3/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9022119 0.83 SRD5A2 (0.56) SRD5A2SRD5A1
SCHEMBL9022266 0.77 SRD5A2 (0.45) SRD5A2SRD5A1
SCHEMBL7757836 0.76 SRD5A1 (0.49) SRD5A2SRD5A1
SCHEMBL9021993 0.76 SRD5A2 (0.64) SRD5A2SRD5A1
SCHEMBL9021998 0.73 SRD5A1 (0.65) SRD5A2SRD5A1
SCHEMBL9022362 0.73 SRD5A1 (0.74) SRD5A2SRD5A1
SCHEMBL9022351 0.73 SRD5A1 (0.74) SRD5A2SRD5A1
SCHEMBL9208220 0.72 SRD5A1 (0.52) SRD5A2SRD5A1
SCHEMBL5908153 0.72 SRD5A2 (0.80) SRD5A2SRD5A1
SCHEMBL7000399 0.72 SRD5A2 (0.80) SRD5A2SRD5A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0484094-B1 Azasteroid compounds for the treatment of prostatic hypertrophy, their preparation and use SANKYO CO (JP) 1996-06-26 EP claimed
US-5302621-A Azasteroid compounds for the treatment of prostatic hypertrophy, their preparation and use SANKYO COMPANY, LIMITED (JP) 1994-04-12 US claimed
EP-0484094-A2 Azasteroid compounds for the treatment of prostatic hypertrophy, their preparation and use Sankyo Company Limited (JP) 1992-05-06 EP claimed
EP-0484094-B1 Azasteroid compounds for the treatment of prostatic hypertrophy, their preparation and use SANKYO CO (JP) 1996-06-26 EP disclosed
US-5302621-A Azasteroid compounds for the treatment of prostatic hypertrophy, their preparation and use SANKYO COMPANY, LIMITED (JP) 1994-04-12 US disclosed
EP-0484094-A2 Azasteroid compounds for the treatment of prostatic hypertrophy, their preparation and use Sankyo Company Limited (JP) 1992-05-06 EP disclosed