SCHEMBL9022351

SCHEMBL9022351

CN1C(=O)CC[C@]2(C)[C@H]3CC[C@]4(C)[C@@H](C(=O)N(Cc5ccccc5)Cc5ccccc5)CC[C@H]4[C@@H]3CC[C@@H]12

nearest known ligand 0.74

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
SRD5A1 P18405 4/20 0.74
SRD5A2 P31213 3/20 0.74

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9022362 1.00 SRD5A1 (0.74) SRD5A1SRD5A2
SCHEMBL852296 0.85 SRD5A1 (1.00) SRD5A1SRD5A2
SCHEMBL11154269 0.85 SRD5A1 (1.00) SRD5A1SRD5A2
SCHEMBL733345 0.85 SRD5A1 (1.00) SRD5A1SRD5A2
SCHEMBL3367052 0.85 SRD5A1 (1.00) SRD5A1SRD5A2
SCHEMBL7000399 0.83 SRD5A2 (0.80) SRD5A1SRD5A2
SCHEMBL5908153 0.83 SRD5A2 (0.80) SRD5A1SRD5A2
SCHEMBL9022510 0.83 SRD5A2 (0.62) SRD5A2
SCHEMBL9022516 0.83 SRD5A2 (0.62) SRD5A2
SCHEMBL9021993 0.82 SRD5A2 (0.64) SRD5A1SRD5A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0484094-B1 Azasteroid compounds for the treatment of prostatic hypertrophy, their preparation and use SANKYO CO (JP) 1996-06-26 EP disclosed
US-5302621-A Azasteroid compounds for the treatment of prostatic hypertrophy, their preparation and use SANKYO COMPANY, LIMITED (JP) 1994-04-12 US disclosed
EP-0484094-A2 Azasteroid compounds for the treatment of prostatic hypertrophy, their preparation and use Sankyo Company Limited (JP) 1992-05-06 EP disclosed