SCHEMBL9022281

SCHEMBL9022281

CN1C(=O)CC[C@@]2(C)C1=CC[C@H]1[C@@H]3CC[C@H](C(=O)N(Nc4ccccc4)c4ccccc4)[C@@]3(C)CC[C@@H]12

nearest known ligand 0.68

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
SRD5A1 P18405 6/20 0.54
SRD5A2 P31213 10/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9022288 0.85 SRD5A2 (0.61) SRD5A1SRD5A2
SCHEMBL5213927 0.85 SRD5A2 (0.59) SRD5A1SRD5A2
SCHEMBL5213919 0.85 SRD5A2 (0.59) SRD5A1SRD5A2
SCHEMBL9022870 0.83 SRD5A2 (0.61) SRD5A1SRD5A2
SCHEMBL9022872 0.83 SRD5A2 (0.61) SRD5A1SRD5A2
SCHEMBL9022075 0.82 SRD5A1 (0.64) SRD5A1SRD5A2
SCHEMBL9022079 0.82 SRD5A1 (0.64) SRD5A1SRD5A2
SCHEMBL5218487 0.82 SRD5A1 (0.64) SRD5A1SRD5A2
SCHEMBL11416876 0.82 SRD5A1 (0.64) SRD5A1SRD5A2
SCHEMBL11154133 0.81 SRD5A2 (0.65) SRD5A1SRD5A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0484094-B1 Azasteroid compounds for the treatment of prostatic hypertrophy, their preparation and use SANKYO CO (JP) 1996-06-26 EP claimed
US-5302621-A Azasteroid compounds for the treatment of prostatic hypertrophy, their preparation and use SANKYO COMPANY, LIMITED (JP) 1994-04-12 US claimed
EP-0484094-A2 Azasteroid compounds for the treatment of prostatic hypertrophy, their preparation and use Sankyo Company Limited (JP) 1992-05-06 EP claimed
EP-0484094-B1 Azasteroid compounds for the treatment of prostatic hypertrophy, their preparation and use SANKYO CO (JP) 1996-06-26 EP disclosed
US-5302621-A Azasteroid compounds for the treatment of prostatic hypertrophy, their preparation and use SANKYO COMPANY, LIMITED (JP) 1994-04-12 US disclosed
EP-0484094-A2 Azasteroid compounds for the treatment of prostatic hypertrophy, their preparation and use Sankyo Company Limited (JP) 1992-05-06 EP disclosed