Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 4/20 | 0.35 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.35 |
| ▸ | NPY5R | Q15761 | 4/20 | 0.34 |
| ▸ | LIPG | Q9Y5X9 | 2/20 | 0.33 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.33 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | LPL | P06858 | 1/20 | 0.33 |
| ▸ | KMO | O15229 | 1/20 | 0.32 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14905665 | 0.82 | NOTUM (0.40) | NOTUMNPY5R | |
| SCHEMBL30814862 | 0.82 | NPY5R (0.42) | NPY5RLIPGFFAR4LPL | |
| SCHEMBL14322213 | 0.82 | NPY5R (0.42) | NPY5RLIPGFFAR4LPL | |
| SCHEMBL2523673 | 0.81 | NOTUM (0.36) | NOTUMLIPGFFAR4ROCK1LPL | |
| SCHEMBL2190473 | 0.81 | LPL (0.39) | NPY5RLIPGLPL | |
| SCHEMBL901845 | 0.80 | NPY5R (0.50) | NOTUMGPR119NPY5RSMN1; SMN2HSD17B10 | |
| SCHEMBL1841187 | 0.79 | USP30 (0.38) | GPR119USP30 | |
| SCHEMBL16924877 | 0.78 | USP30 (0.42) | SMN1; SMN2USP30 | |
| SCHEMBL14322397 | 0.78 | PDK2 (0.47) | NOTUMLIPGFFAR4ROCK1LPL | |
| SCHEMBL901529 | 0.78 | NPY5R (0.41) | NOTUMNPY5RFFAR4MAPK1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2441755-A1 | Pyridine- and isoquinoline-derivatives as Syk and JAK kinase inhibitors | Almirall, S.A. (ES) | 2012-04-18 | — | — | EP | disclosed |