Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTB4R | Q15722 | 18/20 | 0.64 |
| ▸ | LTB4R2 | Q9NPC1 | 17/20 | 0.64 |
| ▸ | TSPO | P30536 | 1/20 | 0.40 |
| ▸ | ICMT | O60725 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9023087 | 1.00 | LTB4R (0.64) | LTB4RLTB4R2TSPOICMT | |
| SCHEMBL9022752 | 0.90 | LTB4R (0.74) | LTB4RLTB4R2TSPO | |
| SCHEMBL9022755 | 0.90 | LTB4R (0.74) | LTB4RLTB4R2TSPO | |
| SCHEMBL9022957 | 0.88 | LTB4R (0.69) | LTB4RLTB4R2 | |
| SCHEMBL9022953 | 0.88 | LTB4R (0.69) | LTB4RLTB4R2 | |
| SCHEMBL9023315 | 0.87 | LTB4R (0.73) | LTB4RLTB4R2 | |
| SCHEMBL9022634 | 0.87 | LTB4R (0.84) | LTB4RLTB4R2 | |
| SCHEMBL9023229 | 0.87 | LTB4R (0.84) | LTB4RLTB4R2 | |
| SCHEMBL9022627 | 0.87 | LTB4R (0.84) | LTB4RLTB4R2 | |
| SCHEMBL9022865 | 0.85 | LTB4R (0.73) | LTB4RLTB4R2TSPO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0548250-B1 | SUBSTITUTED BICYCLIC ARYL COMPOUNDS EXHIBITING SELECTIVE LEUKOTRIENE B4 ANTAGONIST ACTIVITY | RHONE POULENC RORER INT (US) | 1996-03-27 | — | — | EP | disclosed |
| US-5468898-A | Substituted naphthylene compounds exhibiting selective leukotriene B4 antagonist activity | RHONE-POULENC RORER PHARMACEUTICALS INC. (US) | 1995-11-21 | — | — | US | disclosed |
| EP-0548250-A4 | SUBSTITUTED BICYCLIC ARYL COMPOUNDS EXHIBITING SELECTIVE LEUKOTRIENE B 4? ANTAGONIST ACTIVITY | — | 1993-10-27 | — | — | EP | disclosed |
| EP-0548250-A1 | SUBSTITUTED BICYCLIC ARYL COMPOUNDS EXHIBITING SELECTIVE LEUKOTRIENE B 4? ANTAGONIST ACTIVITY. | RHONE POULENC RORER INT (US) | 1993-06-30 | — | — | EP | disclosed |
| WO-1992004321-A1 | SUBSTITUTED BICYCLIC ARYL COMPOUNDS EXHIBITING SELECTIVE LEUKOTRIENE B4 ANTAGONIST ACTIVITY | RHONE-POULENC RORER INTERNATIONAL (HOLDINGS) INC. (US) | 1992-03-19 | — | — | WO | disclosed |