Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 1/20 | 0.52 |
| ▸ | SCN9A | Q15858 | 12/20 | 0.49 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | KLK7 | P49862 | 1/20 | 0.46 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.46 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.45 |
| ▸ | PSMB9 | P28065 | 1/20 | 0.45 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.45 |
| ▸ | IDO1 | P14902 | 1/20 | 0.44 |
| ▸ | CCKAR | P32238 | 1/20 | 0.44 |
| ▸ | CCKBR | P32239 | 1/20 | 0.44 |
| ▸ | CACNA1C | Q13936 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15414301 | 0.87 | SCN9A (0.54) | SCN9AIDO1CCKARCCKBRCACNA1C | |
| SCHEMBL15414303 | 0.87 | SCN9A (0.54) | SCN9AIDO1CCKARCCKBRCACNA1C | |
| SCHEMBL15414247 | 0.87 | SCN9A (0.54) | SCN9AIDO1CCKARCCKBRCACNA1C | |
| SCHEMBL9025396 | 0.85 | SCN9A (0.53) | SCN9AIDO1CCKARCCKBRCACNA1C | |
| SCHEMBL9025761 | 0.84 | SCN9A (0.68) | SCN9ACCKARCCKBR | |
| SCHEMBL9024344 | 0.83 | ACE (0.46) | ACE | |
| SCHEMBL9025395 | 0.83 | PYGL (0.46) | ACEIDO1 | |
| SCHEMBL29481025 | 0.82 | PYGL (0.50) | SCN9AIDO1CACNA1C | |
| SCHEMBL9024786 | 0.81 | PYGL (0.47) | ACE | |
| SCHEMBL15414265 | 0.80 | SCN9A (0.47) | SCN9AIDO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0513974-B1 | Novel benzo-fused lactams that promote the release of growth hormone | MERCK & CO INC (US) | 1996-09-04 | — | — | EP | disclosed |
| US-5310737-A | Benzo-fused lactams that promote the release of growth hormone | MERCK & CO., INC. (US) | 1994-05-10 | — | — | US | disclosed |
| US-5206235-A | Animal growth regulators; stimulants | MERCK & CO., INC. (US) | 1993-04-27 | — | — | US | disclosed |
| EP-0513974-A1 | Novel benzo-fused lactams that promote the release of growth hormone | MERCK & CO. INC. (US) | 1992-11-19 | — | — | EP | disclosed |
| WO-1992016524-A1 | BENZO-FUSED LACTAMS PROMOTE RELEASE OF GROWTH HORMONE | MERCK & CO., INC. (US) | 1992-10-01 | — | — | WO | disclosed |