Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.34 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | CRBN | Q96SW2 | 6/20 | 0.33 |
| ▸ | DDB1 | Q16531 | 5/20 | 0.33 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.32 |
| ▸ | TYMS | P04818 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9025693 | 0.83 | MAPT (0.35) | MAPTUSP2ALDH1A1PTGS1PTGS2 | |
| SCHEMBL17321237 | 0.81 | SRD5A1 (0.39) | ALDH1A1CRBNDDB1RIPK1 | |
| SCHEMBL15964662 | 0.78 | AHR (0.50) | RIPK1 | |
| SCHEMBL2361761 | 0.78 | HTR5A (0.40) | MAPTCRBNDDB1 | |
| SCHEMBL15964664 | 0.78 | BRD4 (0.45) | MAPTCRBNDDB1RIPK1 | |
| SCHEMBL9025593 | 0.77 | PDE3B (0.51) | MAPTALDH1A1SMN1; SMN2CRBNDDB1 | |
| SCHEMBL9025886 | 0.74 | KMT2A (0.49) | CRBNDDB1 | |
| SCHEMBL7086240 | 0.73 | NPC1 (0.52) | MAPTALDH1A1KDM4EGAAHPGD | |
| SCHEMBL9025127 | 0.73 | MAPT (0.53) | MAPTUSP2ALDH1A1SMN1; SMN2 | |
| SCHEMBL18743979 | 0.72 | HTR5A (0.40) | ALDH1A1CRBNDDB1RIPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0513974-B1 | Novel benzo-fused lactams that promote the release of growth hormone | MERCK & CO INC (US) | 1996-09-04 | — | — | EP | disclosed |
| US-5310737-A | Benzo-fused lactams that promote the release of growth hormone | MERCK & CO., INC. (US) | 1994-05-10 | — | — | US | disclosed |
| US-5206235-A | Animal growth regulators; stimulants | MERCK & CO., INC. (US) | 1993-04-27 | — | — | US | disclosed |
| EP-0513974-A1 | Novel benzo-fused lactams that promote the release of growth hormone | MERCK & CO. INC. (US) | 1992-11-19 | — | — | EP | disclosed |
| WO-1992016524-A1 | BENZO-FUSED LACTAMS PROMOTE RELEASE OF GROWTH HORMONE | MERCK & CO., INC. (US) | 1992-10-01 | — | — | WO | disclosed |