Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | XIAP | P98170 | 5/20 | 0.58 |
| ▸ | ACE | P12821 | 6/20 | 0.49 |
| ▸ | MME | P08473 | 3/20 | 0.49 |
| ▸ | SCN9A | Q15858 | 3/20 | 0.47 |
| ▸ | NPY1R | P25929 | 2/20 | 0.47 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.47 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.47 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9024580 | 0.95 | XIAP (0.59) | XIAPACEMMESCN9ANPY1R | |
| SCHEMBL9024759 | 0.91 | XIAP (0.57) | XIAPACEMMESCN9ANPY1R | |
| SCHEMBL9024198 | 0.84 | XIAP (0.66) | XIAPACEMMENPY1R | |
| SCHEMBL9025448 | 0.83 | GHSR (0.55) | XIAPNPY1R | |
| SCHEMBL9024904 | 0.83 | GHSR (0.55) | XIAPACEMMENPY1R | |
| SCHEMBL9023926 | 0.83 | GHSR (0.55) | XIAPACEMMENPY1R | |
| SCHEMBL9087738 | 0.82 | GHSR (0.56) | XIAPNPY1R | |
| SCHEMBL9024266 | 0.82 | GHSR (0.53) | XIAPSCN9ANPY1R | |
| SCHEMBL9025136 | 0.82 | GHSR (0.53) | XIAPNPY1R | |
| SCHEMBL9024480 | 0.81 | GHSR (0.53) | XIAPNPY1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0513974-B1 | Novel benzo-fused lactams that promote the release of growth hormone | MERCK & CO INC (US) | 1996-09-04 | — | — | EP | disclosed |
| US-5206235-A | Animal growth regulators; stimulants | MERCK & CO., INC. (US) | 1993-04-27 | — | — | US | disclosed |
| EP-0513974-A1 | Novel benzo-fused lactams that promote the release of growth hormone | MERCK & CO. INC. (US) | 1992-11-19 | — | — | EP | disclosed |
| WO-1992016524-A1 | BENZO-FUSED LACTAMS PROMOTE RELEASE OF GROWTH HORMONE | MERCK & CO., INC. (US) | 1992-10-01 | — | — | WO | disclosed |