Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR2 | P50052 | 6/20 | 0.40 |
| ▸ | USP1 | O94782 | 4/20 | 0.37 |
| ▸ | WDR48 | Q8TAF3 | 4/20 | 0.37 |
| ▸ | AGTR1 | P30556 | 4/20 | 0.36 |
| ▸ | PDE4A | P27815 | 1/20 | 0.36 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.36 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.36 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.36 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.36 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9024512 | 0.99 | AGTR2 (0.41) | AGTR2USP1WDR48AGTR1PDE4A | |
| SCHEMBL9023801 | 0.98 | AGTR2 (0.40) | AGTR2USP1WDR48AGTR1PDE4A | |
| SCHEMBL9024586 | 0.90 | AGTR2 (0.39) | AGTR2AGTR1PDE4APDE4BPDE4C | |
| SCHEMBL9024426 | 0.89 | PDE4A (0.42) | AGTR2AGTR1PDE4APDE4BPDE4C | |
| SCHEMBL9024358 | 0.89 | AGTR2 (0.40) | AGTR2AGTR1PDE4APDE4BPDE4C | |
| SCHEMBL9024574 | 0.88 | AGTR2 (0.39) | AGTR2AGTR1PDE4APDE4BPDE4C | |
| SCHEMBL9024268 | 0.88 | PDE4A (0.43) | AGTR2AGTR1PDE4APDE4BPDE4C | |
| SCHEMBL9024410 | 0.87 | PDE4A (0.42) | AGTR2AGTR1PDE4APDE4BPDE4C | |
| SCHEMBL9024049 | 0.87 | AGTR2 (0.38) | AGTR2AGTR1PDE4APDE4BPDE4C | |
| SCHEMBL9025352 | 0.85 | AGTR2 (0.39) | AGTR2USP1WDR48AGTR1PDE4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0611368-B1 | SUBSTITUTED AMINOPYRIMIDINES AS ANGIOTENSIN II ANTAGONISTS | AMERICAN HOME PROD (US) | 1996-02-07 | — | — | EP | disclosed |
| US-5336677-A | ANTAGONIST OF ANGIOTENSIN II | AMERICAN HOME PRODUCTS CORPORATION (US) | 1994-08-09 | — | — | US | disclosed |