Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NQO2 | P16083 | 8/20 | 0.38 |
| ▸ | NQO1 | P15559 | 8/20 | 0.38 |
| ▸ | TOP2A | P11388 | 2/20 | 0.36 |
| ▸ | IDO1 | P14902 | 2/20 | 0.33 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.32 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.32 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.32 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.32 |
| ▸ | FLT4 | P35916 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.31 |
| ▸ | USP2 | O75604 | 2/20 | 0.31 |
| ▸ | LMNA | P02545 | 2/20 | 0.31 |
| ▸ | TP53 | P04637 | 2/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.31 |
| ▸ | RECQL | P46063 | 2/20 | 0.31 |
| ▸ | BLM | P54132 | 2/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9024127 | 0.95 | TOP2A (0.40) | NQO2NQO1TOP2ACSNK2A1DYRK3 | |
| SCHEMBL9024437 | 0.95 | NQO2 (0.37) | NQO2NQO1IDO1HTTMAPT | |
| SCHEMBL9023958 | 0.93 | TOP2A (0.42) | NQO2NQO1TOP2ACSNK2A1DYRK3 | |
| SCHEMBL9023814 | 0.92 | NQO2 (0.36) | NQO2NQO1TOP2AIDO1HTT | |
| SCHEMBL9024632 | 0.91 | NQO1 (0.35) | NQO2NQO1TOP2A | |
| SCHEMBL9023942 | 0.91 | NQO1 (0.35) | NQO2NQO1TOP2A | |
| SCHEMBL9023868 | 0.90 | NQO2 (0.38) | NQO2NQO1TOP2AIDO1MEN1 | |
| SCHEMBL8543978 | 0.89 | IDO1 (0.35) | NQO2NQO1TOP2AIDO1CSNK2A1 | |
| SCHEMBL10517310 | 0.87 | NQO2 (0.37) | NQO2NQO1TOP2AIDO1HTT | |
| SCHEMBL9025443 | 0.86 | NQO2 (0.37) | NQO2NQO1TOP2AIDO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0347749-B1 | Pyrazoloacridone derivatives with anti-tumoral activity | KYOWA HAKKO KOGYO KK (JP) | 1996-04-24 | — | — | EP | claimed |
| EP-0347749-A2 | Pyrazoloacridone derivatives with anti-tumoral activity | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1989-12-27 | — | — | EP | claimed |
| EP-0347749-B1 | Pyrazoloacridone derivatives with anti-tumoral activity | KYOWA HAKKO KOGYO KK (JP) | 1996-04-24 | — | — | EP | disclosed |
| US-5079358-A | Humans; leukemia | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1992-01-07 | — | — | US | disclosed |
| EP-0347749-A2 | Pyrazoloacridone derivatives with anti-tumoral activity | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1989-12-27 | — | — | EP | disclosed |