Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NQO2 | P16083 | 10/20 | 0.38 |
| ▸ | NQO1 | P15559 | 8/20 | 0.38 |
| ▸ | IDO1 | P14902 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | TOP2A | P11388 | 1/20 | 0.31 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.31 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.31 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.31 |
| ▸ | NSD2 | O96028 | 1/20 | 0.30 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.30 |
| ▸ | MITF | O75030 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9023814 | 0.94 | NQO2 (0.36) | NQO2NQO1IDO1TOP2AMITF | |
| SCHEMBL9024437 | 0.94 | NQO2 (0.37) | NQO2NQO1IDO1MITF | |
| SCHEMBL10519205 | 0.92 | NQO2 (0.38) | NQO2NQO1IDO1TOP2AGRIN1 | |
| SCHEMBL9024127 | 0.91 | TOP2A (0.40) | NQO2NQO1MEN1ALDH1A1KMT2A | |
| SCHEMBL9025443 | 0.91 | NQO2 (0.37) | NQO2NQO1IDO1TOP2A | |
| SCHEMBL9024018 | 0.90 | NQO2 (0.38) | NQO2NQO1IDO1MEN1ALDH1A1 | |
| SCHEMBL9023796 | 0.88 | NQO2 (0.47) | NQO2NQO1ALDH1A1HPGDHSD17B10 | |
| SCHEMBL9023958 | 0.88 | TOP2A (0.42) | NQO2NQO1MEN1ALDH1A1KMT2A | |
| SCHEMBL9024299 | 0.86 | NQO2 (0.49) | NQO2NQO1IDO1GRIN1GRIN2A | |
| SCHEMBL9024397 | 0.86 | TOP2A (0.40) | NQO2NQO1TOP2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0347749-B1 | Pyrazoloacridone derivatives with anti-tumoral activity | KYOWA HAKKO KOGYO KK (JP) | 1996-04-24 | — | — | EP | claimed |
| EP-0347749-B1 | Pyrazoloacridone derivatives with anti-tumoral activity | KYOWA HAKKO KOGYO KK (JP) | 1996-04-24 | — | — | EP | disclosed |
| US-5079358-A | Humans; leukemia | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1992-01-07 | — | — | US | disclosed |
| EP-0347749-A2 | Pyrazoloacridone derivatives with anti-tumoral activity | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1989-12-27 | — | — | EP | disclosed |