Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 1/20 | 0.44 |
| ▸ | DRD3 | P35462 | 1/20 | 0.44 |
| ▸ | HTR5A | P47898 | 1/20 | 0.42 |
| ▸ | AADAT | Q8N5Z0 | 2/20 | 0.40 |
| ▸ | CRBN | Q96SW2 | 3/20 | 0.39 |
| ▸ | DDB1 | Q16531 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | SRD5A1 | P18405 | 1/20 | 0.36 |
| ▸ | IL1RN | P18510 | 1/20 | 0.34 |
| ▸ | ERAP2 | Q6P179 | 1/20 | 0.34 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4067227 | 0.84 | AADAT (0.49) | DRD2DRD3HTR5AAADATCRBN | |
| SCHEMBL22469572 | 0.81 | CRBN (0.39) | DRD2DRD3HTR5AAADATCRBN | |
| SCHEMBL432630 | 0.81 | CRBN (0.39) | DRD2DRD3HTR5AAADATCRBN | |
| SCHEMBL27001908 | 0.77 | IL1RN (0.36) | IL1RNERAP2ERAP1 | |
| SCHEMBL27001873 | 0.77 | IL1RN (0.36) | IL1RNERAP2ERAP1 | |
| SCHEMBL22469835 | 0.75 | CRBN (0.49) | CRBNDDB1 | |
| SCHEMBL15368226 | 0.75 | DDB1 (0.35) | DRD2DRD3HTR5ACRBNDDB1 | |
| SCHEMBL1270418 | 0.73 | NPC1 (0.52) | IL1RNERAP2ERAP1 | |
| SCHEMBL13904707 | 0.73 | NPC1 (0.52) | IL1RNERAP2ERAP1 | |
| SCHEMBL1270022 | 0.73 | NPC1 (0.52) | IL1RNERAP2ERAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0513974-B1 | Novel benzo-fused lactams that promote the release of growth hormone | MERCK & CO INC (US) | 1996-09-04 | — | — | EP | disclosed |
| US-5206235-A | Animal growth regulators; stimulants | MERCK & CO., INC. (US) | 1993-04-27 | — | — | US | disclosed |
| EP-0513974-A1 | Novel benzo-fused lactams that promote the release of growth hormone | MERCK & CO. INC. (US) | 1992-11-19 | — | — | EP | disclosed |
| WO-1992016524-A1 | BENZO-FUSED LACTAMS PROMOTE RELEASE OF GROWTH HORMONE | MERCK & CO., INC. (US) | 1992-10-01 | — | — | WO | disclosed |