Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAU | P00749 | 1/20 | 0.52 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | ANPEP | P15144 | 4/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.37 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.37 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4703041 | 1.00 | PLAU (0.52) | PLAUSMYD3ALOX15HSD17B10MEN1 | |
| SCHEMBL29350964 | 1.00 | PLAU (0.52) | PLAUSMYD3ALOX15HSD17B10MEN1 | |
| SCHEMBL9691688 | 0.89 | MAPT (0.41) | PLAUSMYD3ALOX15HSD17B10MEN1 | |
| Fumaric Acid SCHEMBL11638981 | 0.86 | SMYD3 (0.43) | PLAUSMYD3GAAMAPT | |
| Fumaric Acid SCHEMBL11638993 | 0.86 | SMYD3 (0.43) | PLAUSMYD3GAAMAPT | |
| SCHEMBL30576492 | 0.80 | PLAU (0.45) | PLAUALOX15HSD17B10MEN1KMT2A | |
| SCHEMBL2030277 | 0.80 | PLAU (0.45) | PLAUALOX15HSD17B10MEN1KMT2A | |
| SCHEMBL3825586 | 0.80 | PLAU (0.45) | PLAUALOX15HSD17B10MEN1KMT2A | |
| SCHEMBL8567210 | 0.80 | PLAU (0.45) | PLAUALOX15HSD17B10MEN1KMT2A | |
| Indoline SCHEMBL2111659 | 0.78 | PLAU (0.44) | PLAUSMYD3ALOX15HSD17B10MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0513974-B1 | Novel benzo-fused lactams that promote the release of growth hormone | MERCK & CO INC (US) | 1996-09-04 | — | — | EP | disclosed |
| EP-0665748-A4 | BENZO-FUSED LACTAMS PROMOTE RELEASE OF GROWTH HORMONE. | — | 1995-08-23 | — | — | EP | disclosed |
| EP-0665748-A1 | BENZO-FUSED LACTAMS PROMOTE RELEASE OF GROWTH HORMONE | MERCK & CO. INC. (US) | 1995-08-09 | — | — | EP | disclosed |
| EP-0513974-A1 | Novel benzo-fused lactams that promote the release of growth hormone | MERCK & CO. INC. (US) | 1992-11-19 | — | — | EP | disclosed |