Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | PLAU | P00749 | 1/20 | 0.40 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.39 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.39 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.39 |
| ▸ | IDO1 | P14902 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | BLM | P54132 | 1/20 | 0.38 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.38 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29350964 | 0.89 | PLAU (0.52) | MAPTPLAUMEN1KMT2ASMYD3 | |
| SCHEMBL4703041 | 0.89 | PLAU (0.52) | MAPTPLAUMEN1KMT2ASMYD3 | |
| SCHEMBL9024447 | 0.89 | PLAU (0.52) | MAPTPLAUMEN1KMT2ASMYD3 | |
| SCHEMBL30576492 | 0.77 | PLAU (0.45) | MAPTPLAUMEN1KMT2AALOX15 | |
| SCHEMBL8567210 | 0.77 | PLAU (0.45) | MAPTPLAUMEN1KMT2AALOX15 | |
| SCHEMBL2030277 | 0.77 | PLAU (0.45) | MAPTPLAUMEN1KMT2AALOX15 | |
| SCHEMBL3825586 | 0.77 | PLAU (0.45) | MAPTPLAUMEN1KMT2AALOX15 | |
| Fumaric Acid SCHEMBL11638993 | 0.77 | SMYD3 (0.43) | MAPTPLAUBLMTAAR1SMYD3 | |
| Fumaric Acid SCHEMBL11638981 | 0.77 | SMYD3 (0.43) | MAPTPLAUBLMTAAR1SMYD3 | |
| Indoline SCHEMBL2111659 | 0.76 | PLAU (0.44) | MAPTPLAUMEN1KMT2ASMYD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0166354-B1 | BENZOFUSED LACTAM COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | MERCK & CO. INC. (US) | 1992-08-05 | — | — | EP | disclosed |
| US-4873235-A | COUPLING KETO ESTER WITH LACTAM; ANGIOTENSIN CONVERTING ENZYME INHIBITORS | MERCK & CO., INC. (US) | 1989-10-10 | — | — | US | disclosed |
| US-4684645-A | GASTROINTESTINAL AND NERVOUS SYSTEM DISORDERS | MERCK & CO., INC. (US) | 1987-08-04 | — | — | US | disclosed |
| EP-0166354-A2 | Benzofused lactam compounds and pharmaceutical compositions containing them | MERCK & CO. INC. (US) | 1986-01-02 | — | — | EP | disclosed |