Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.47 |
| ▸ | TP53 | P04637 | 6/20 | 0.47 |
| ▸ | SENP5 | Q96HI0 | 3/20 | 0.46 |
| ▸ | SENP2 | Q9HC62 | 3/20 | 0.46 |
| ▸ | SENP1 | Q9P0U3 | 3/20 | 0.46 |
| ▸ | NMT1 | P30419 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | ACHE | P22303 | 2/20 | 0.43 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL9303740 | 0.96 | MAPT (0.46) | MAPTTP53SENP5SENP2SENP1 | |
| SCHEMBL9024516 | 0.80 | SENP5 (0.48) | MAPTSENP5SENP2SENP1NMT1 | |
| SCHEMBL9024033 | 0.80 | SENP5 (0.48) | MAPTSENP5SENP2SENP1NMT1 | |
| Hydrochloric Acid SCHEMBL9306109 | 0.79 | SENP5 (0.48) | MAPTSENP5SENP2SENP1NMT1 | |
| Hydrochloric Acid SCHEMBL9304756 | 0.79 | SENP5 (0.48) | MAPTSENP5SENP2SENP1NMT1 | |
| Hydrochloric Acid SCHEMBL9303745 | 0.78 | SENP5 (0.49) | MAPTSENP5SENP2SENP1NMT1 | |
| Hydrochloric Acid SCHEMBL9024501 | 0.77 | CXCR4 (0.51) | MAPTSENP5SENP2SENP1NMT1 | |
| SCHEMBL11801079 | 0.77 | SENP5 (0.52) | MAPTTP53SENP5SENP2SENP1 | |
| Hydrochloric Acid SCHEMBL9305852 | 0.77 | SENP5 (0.48) | MAPTSENP5SENP2SENP1NMT1 | |
| Hydrochloric Acid SCHEMBL9304862 | 0.76 | SENP5 (0.47) | MAPTSENP5SENP2SENP1NMT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0543584-B1 | Benzo(b)thiophene-2-carboxamides for the treatment of disorders of the central nervous system | LILLY INDUSTRIES LTD (GB) | 1996-05-22 | — | — | EP | disclosed |
| US-5338735-A | For treatment of central nervous system disorders | LILLY INDUSTRIES LIMITED (GB) | 1994-08-16 | — | — | US | disclosed |
| EP-0543584-A1 | Benzo(b)thiophene-2-carboxamides for the treatment of disorders of the central nervous system | LILLY INDUSTRIES LIMITED (GB) | 1993-05-26 | — | — | EP | disclosed |