Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBXA2R | P21731 | 6/20 | 0.41 |
| ▸ | PTGDR | Q13258 | 2/20 | 0.41 |
| ▸ | TBXAS1 | P24557 | 3/20 | 0.40 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9006118 | 1.00 | TBXA2R (0.41) | TBXA2RPTGDRTBXAS1EGFRERBB2 | |
| SCHEMBL9006199 | 0.97 | TBXA2R (0.43) | TBXA2RPTGDRTBXAS1ALDH1A1LMNA | |
| SCHEMBL9646098 | 0.97 | TBXA2R (0.43) | TBXA2RPTGDRTBXAS1ALDH1A1LMNA | |
| SCHEMBL9006193 | 0.97 | TBXA2R (0.43) | TBXA2RPTGDRTBXAS1ALDH1A1LMNA | |
| SCHEMBL9006145 | 0.93 | TBXA2R (0.41) | TBXA2RPTGDRTBXAS1ALDH1A1LMNA | |
| SCHEMBL9006151 | 0.93 | TBXA2R (0.41) | TBXA2RPTGDRTBXAS1ALDH1A1LMNA | |
| SCHEMBL9006242 | 0.93 | PTGDR (0.43) | TBXA2RPTGDRTBXAS1EGFRERBB2 | |
| SCHEMBL9024412 | 0.93 | PTGDR (0.43) | TBXA2RPTGDRTBXAS1EGFRERBB2 | |
| SCHEMBL9006089 | 0.92 | PTGDR (0.47) | TBXA2RPTGDRTBXAS1ALDH1A1MEN1 | |
| SCHEMBL9006133 | 0.92 | TBXA2R (0.47) | TBXA2RPTGDRTBXAS1ALDH1A1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0367130-B1 | Pyrrolidine derivatives | FUJISAWA PHARMACEUTICAL CO (JP) | 1996-10-02 | — | — | EP | disclosed |
| US-5264453-A | Pyrrolidine derivatives | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1993-11-23 | — | — | US | disclosed |
| US-5130323-A | PYRROLIDINE DERIVATIVES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1992-07-14 | — | — | US | disclosed |
| EP-0367130-A2 | Pyrrolidine derivatives | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1990-05-09 | — | — | EP | disclosed |