Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR | Q13258 | 3/20 | 0.43 |
| ▸ | EGFR | P00533 | 1/20 | 0.42 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.42 |
| ▸ | MMP2 | P08253 | 2/20 | 0.41 |
| ▸ | MMP1 | P03956 | 2/20 | 0.41 |
| ▸ | MMP13 | P45452 | 2/20 | 0.41 |
| ▸ | MMP3 | P08254 | 1/20 | 0.41 |
| ▸ | MMP7 | P09237 | 1/20 | 0.41 |
| ▸ | TBXA2R | P21731 | 4/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.39 |
| ▸ | MMP9 | P14780 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9006242 | 1.00 | PTGDR (0.43) | PTGDREGFRERBB2MMP2MMP1 | |
| SCHEMBL9006199 | 0.96 | TBXA2R (0.43) | PTGDRTBXA2RTBXAS1ALDH1A1LMNA | |
| SCHEMBL9006193 | 0.96 | TBXA2R (0.43) | PTGDRTBXA2RTBXAS1ALDH1A1LMNA | |
| SCHEMBL9646098 | 0.96 | TBXA2R (0.43) | PTGDRTBXA2RTBXAS1ALDH1A1LMNA | |
| SCHEMBL9006148 | 0.93 | PTGDR (0.51) | PTGDREGFRERBB2MMP2MMP1 | |
| SCHEMBL9024212 | 0.93 | PTGDR (0.51) | PTGDREGFRERBB2MMP2MMP1 | |
| SCHEMBL9006145 | 0.93 | TBXA2R (0.41) | PTGDRTBXA2RTBXAS1ALDH1A1LMNA | |
| SCHEMBL9006118 | 0.93 | TBXA2R (0.41) | PTGDREGFRERBB2TBXA2RTBXAS1 | |
| SCHEMBL9024778 | 0.93 | TBXA2R (0.41) | PTGDREGFRERBB2TBXA2RTBXAS1 | |
| SCHEMBL9006151 | 0.93 | TBXA2R (0.41) | PTGDRTBXA2RTBXAS1ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0367130-B1 | Pyrrolidine derivatives | FUJISAWA PHARMACEUTICAL CO (JP) | 1996-10-02 | — | — | EP | disclosed |
| US-5264453-A | Pyrrolidine derivatives | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1993-11-23 | — | — | US | disclosed |
| US-5130323-A | PYRROLIDINE DERIVATIVES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1992-07-14 | — | — | US | disclosed |
| EP-0367130-A2 | Pyrrolidine derivatives | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1990-05-09 | — | — | EP | disclosed |