Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | BCHE | P06276 | 4/20 | 0.40 |
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.39 |
| ▸ | GPR84 | Q9NQS5 | 3/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | AHR | P35869 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9025377 | 0.85 | BCHE (0.43) | MAPTLMNASMN1; SMN2ALDH1A1BCHE | |
| SCHEMBL9025592 | 0.81 | GPR84 (0.45) | MAPTSMN1; SMN2ALDH1A1KMT2AGPR84 | |
| SCHEMBL9026577 | 0.80 | GPR84 (0.44) | MAPTSMN1; SMN2ALDH1A1KMT2AGPR84 | |
| SCHEMBL9026744 | 0.78 | KMT2A (0.49) | MAPTLMNASMN1; SMN2ALDH1A1KMT2A | |
| SCHEMBL9025829 | 0.77 | MAPT (0.42) | MAPTALDH1A1KMT2AGPR84POLB | |
| SCHEMBL9026242 | 0.77 | GPR84 (0.41) | MAPTALDH1A1KMT2AGPR84POLB | |
| SCHEMBL9026776 | 0.77 | KMT2A (0.44) | MAPTLMNAALDH1A1KMT2AGPR84 | |
| SCHEMBL9037121 | 0.76 | KCNA5 (0.41) | MAPTLMNASMN1; SMN2ALDH1A1BCHE | |
| SCHEMBL9025614 | 0.75 | AHR (0.41) | MAPTSMN1; SMN2KMT2AGPR84POLB | |
| SCHEMBL9026860 | 0.72 | KMT2A (0.42) | MAPTLMNASMN1; SMN2ALDH1A1BCHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0411150-B1 | INDOLE DERIVATIVES, PREPARATION THEREOF, AND DRUG FOR PREVENTING AND TREATING NEPHRITIS CONTAINING SAME | OTSUKA PHARMA CO LTD (JP) | 1996-11-27 | — | — | EP | disclosed |
| US-5238938-A | Nephrosis | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1993-08-24 | — | — | US | disclosed |
| EP-0411150-A1 | INDOLE DERIVATIVES, PREPARATION THEREOF, AND DRUG FOR PREVENTING AND TREATING NEPHRITIS CONTAINING SAME | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1991-02-06 | — | — | EP | disclosed |