Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 10/20 | 0.55 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.34 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | IDO1 | P14902 | 2/20 | 0.31 |
| ▸ | AGXT | P21549 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL527586 | 0.86 | ALOX5 (0.72) | ALOX5EPHX2KMT2AALDH1A1MEN1 | |
| SCHEMBL9024981 | 0.85 | ALOX5 (0.50) | ALOX5MAOBPARP10 | |
| SCHEMBL8305231 | 0.85 | ALOX5 (0.58) | ALOX5EPHX2ALDH1A1 | |
| SCHEMBL9024444 | 0.79 | ALOX5 (0.44) | ALOX5MAOBPARP10KMT2AALDH1A1 | |
| SCHEMBL9078235 | 0.78 | ALOX5 (0.55) | ALOX5 | |
| SCHEMBL9023854 | 0.77 | ALOX5 (0.51) | ALOX5EPHX2KMT2AALDH1A1MEN1 | |
| SCHEMBL9025717 | 0.75 | ALOX5 (0.49) | ALOX5EPHX2 | |
| SCHEMBL8305227 | 0.74 | ALOX5 (0.48) | ALOX5EPHX2 | |
| SCHEMBL5986472 | 0.74 | ALOX5 (0.56) | ALOX5EPHX2KMT2AMEN1KCNH2 | |
| SCHEMBL9025000 | 0.74 | ALOX5 (0.56) | ALOX5EPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0667855-A4 | SUBSTITUTED ARYLALKYNYL- AND HETEROARYLALKYNYL-N-HYDROXYUREA INHIBITORS OF LEUKOTRIENE BIOSYNTHESIS. | ABBOTT LAB (US) | 1996-02-21 | — | — | EP | disclosed |
| EP-0667855-A1 | SUBSTITUTED ARYLALKYNYL- AND HETEROARYLALKYNYL-N-HYDROXYUREA INHIBITORS OF LEUKOTRIENE BIOSYNTHESIS | ABBOTT LABORATORIES (US) | 1995-08-23 | — | — | EP | disclosed |
| WO-1994011342-A1 | SUBSTITUTED ARYLALKYNYL- AND HETEROARYLALKYNYL-N-HYDROXYUREA INHIBITORS OF LEUKOTRIENE BIOSYNTHESIS | ABBOTT LABORATORIES (US) | 1994-05-26 | — | — | WO | disclosed |