Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AHR | P35869 | 2/20 | 0.42 |
| ▸ | NR3C1 | P04150 | 11/20 | 0.40 |
| ▸ | NR3C2 | P08235 | 4/20 | 0.39 |
| ▸ | PGR | P06401 | 3/20 | 0.39 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.39 |
| ▸ | HTR1D | P28221 | 1/20 | 0.39 |
| ▸ | HTR1B | P28222 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | HTR2C | P28335 | 1/20 | 0.39 |
| ▸ | HTR1E | P28566 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | HTR7 | P34969 | 1/20 | 0.39 |
| ▸ | HTR2B | P41595 | 1/20 | 0.39 |
| ▸ | HTR6 | P50406 | 1/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.39 |
| ▸ | GPR84 | Q9NQS5 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9026589 | 0.85 | AHR (0.42) | AHRNR3C1NR3C2PGRADRB1 | |
| SCHEMBL9038160 | 0.85 | AHR (0.42) | AHRNR3C1NR3C2PGRADRB1 | |
| SCHEMBL9026609 | 0.85 | HTR6 (0.44) | AHRNR3C1ADRB1HTR1AADRA2A | |
| SCHEMBL9026254 | 0.85 | MAPT (0.44) | AHRADRB1HTR1AADRA2ASLC6A2 | |
| SCHEMBL9026540 | 0.85 | AHR (0.42) | AHRNR3C1NR3C2PGRADRB1 | |
| SCHEMBL9026878 | 0.83 | AHR (0.41) | AHRNR3C1NR3C2PGRADRB1 | |
| SCHEMBL9025829 | 0.83 | MAPT (0.42) | AHRNR3C1ADRB1HTR1AADRA2A | |
| SCHEMBL9026286 | 0.82 | AHR (0.40) | AHRNR3C1NR3C2PGRADRB1 | |
| SCHEMBL9486584 | 0.82 | AHR (0.40) | AHRNR3C1ADRB1HTR1AADRA2A | |
| SCHEMBL9026487 | 0.81 | AHR (0.39) | AHRADRB1HTR1AADRA2ASLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0411150-B1 | INDOLE DERIVATIVES, PREPARATION THEREOF, AND DRUG FOR PREVENTING AND TREATING NEPHRITIS CONTAINING SAME | OTSUKA PHARMA CO LTD (JP) | 1996-11-27 | — | — | EP | disclosed |
| US-5238938-A | Nephrosis | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1993-08-24 | — | — | US | disclosed |
| EP-0411150-A1 | INDOLE DERIVATIVES, PREPARATION THEREOF, AND DRUG FOR PREVENTING AND TREATING NEPHRITIS CONTAINING SAME | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1991-02-06 | — | — | EP | disclosed |