Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 16/20 | 0.74 |
| ▸ | LMNA | P02545 | 1/20 | 0.64 |
| ▸ | CNR1 | P21554 | 3/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4082279 | 0.96 | CNR2 (0.81) | CNR2LMNACNR1 | |
| SCHEMBL30417203 | 0.95 | CNR2 (0.79) | CNR2LMNACNR1 | |
| Water SCHEMBL10469548 | 0.95 | CNR2 (0.79) | CNR2LMNACNR1 | |
| SCHEMBL9029183 | 0.92 | LMNA (0.68) | CNR2LMNACNR1 | |
| SCHEMBL7347589 | 0.90 | CNR2 (0.69) | CNR2CNR1 | |
| SCHEMBL31052987 | 0.86 | CNR2 (0.74) | CNR2CNR1 | |
| SCHEMBL11903673 | 0.86 | CNR2 (0.74) | CNR2CNR1 | |
| SCHEMBL1661468 | 0.85 | LMNA (0.71) | CNR2LMNA | |
| SCHEMBL30421894 | 0.85 | LMNA (0.71) | CNR2LMNA | |
| SCHEMBL18833435 | 0.84 | CNR1 (0.68) | CNR2LMNACNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0494978-B1 | HETEROCYCLIC COMPOUNDS | WYETH JOHN & BROTHER LTD (GB) | 1996-02-28 | — | — | EP | disclosed |
| US-5362734-A | Certain benzo-quinolizine compounds and derivatives thereof | AMERICAN HOME PRODUCTS CORPORATION (US) | 1994-11-08 | — | — | US | disclosed |
| US-5225419-A | Antagonist 5-hydroxytryptamine for treatment of nausea or vomiting | JOHN WYETH & BROTHER, LIMITED (GB) | 1993-07-06 | — | — | US | disclosed |
| EP-0494978-A1 | HETEROCYCLIC COMPOUNDS. | WYETH JOHN & BROTHER LTD (GB) | 1992-07-22 | — | — | EP | disclosed |
| US-5096901-A | PHARMACOLOGICALLY ACTIVE AMIDES AND ESTERS CONTAINING AN AZABICYCLOALKANE MOIETY | JOHN WYETH & BROTHER LIMITED (GB) | 1992-03-17 | — | — | US | disclosed |
| WO-1991005783-A1 | HETEROCYCLIC COMPOUNDS | JOHN WYETH & BROTHER LIMITED (GB) | 1991-05-02 | — | — | WO | disclosed |