Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR2 | P21452 | 7/20 | 0.41 |
| ▸ | TACR1 | P25103 | 6/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 9/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 8/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 6/20 | 0.36 |
| ▸ | TACR3 | P29371 | 2/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | HRH1 | P35367 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9028585 | 0.88 | TACR2 (0.45) | TACR2TACR1SLC6A4SLC6A3SLC6A2 | |
| SCHEMBL9027877 | 0.83 | HRH1 (0.40) | TACR2TACR1SLC6A4SLC6A3TACR3 | |
| SCHEMBL9027247 | 0.82 | SLC6A4 (0.37) | SLC6A4SLC6A3SLC6A2CYP2D6 | |
| SCHEMBL9028256 | 0.82 | TACR2 (0.43) | TACR2TACR1SLC6A4SLC6A3SLC6A2 | |
| SCHEMBL9027507 | 0.82 | SLC6A4 (0.36) | TACR1SLC6A4SLC6A3SLC6A2CYP2D6 | |
| SCHEMBL9028041 | 0.80 | TACR1 (0.49) | TACR2TACR1TACR3HRH1 | |
| SCHEMBL9028269 | 0.80 | MEN1 (0.39) | — | |
| SCHEMBL9027369 | 0.80 | TACR2 (0.49) | TACR2TACR1TACR3HRH1 | |
| SCHEMBL9027802 | 0.80 | TACR2 (0.59) | TACR2TACR1TACR3CYP2D6HRH1 | |
| SCHEMBL9027885 | 0.79 | TACR2 (0.58) | TACR2TACR1TACR3HRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5563133-A | NERVOUS SYSTEM DISORDERS | ELI LILLY AND COMPANY (US) | 1996-10-08 | — | — | US | disclosed |
| EP-0714891-A1 | Heterocyclic tachykinin receptor antagonists | ELI LILLY AND COMPANY (US) | 1996-06-05 | — | — | EP | disclosed |