Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 6/20 | 0.40 |
| ▸ | TACR2 | P21452 | 3/20 | 0.40 |
| ▸ | TACR1 | P25103 | 3/20 | 0.40 |
| ▸ | TACR3 | P29371 | 1/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9028275 | 0.91 | CASP1 (0.39) | HRH1TACR1 | |
| SCHEMBL9028585 | 0.87 | TACR2 (0.45) | HRH1TACR2TACR1TACR3SLC6A4 | |
| SCHEMBL9028256 | 0.86 | TACR2 (0.43) | TACR2TACR1TACR3SLC6A4SLC6A3 | |
| SCHEMBL9027899 | 0.83 | TACR2 (0.41) | HRH1TACR2TACR1TACR3SLC6A4 | |
| SCHEMBL8450883 | 0.80 | TACR2 (0.36) | HRH1TACR2TACR1TACR3 | |
| SCHEMBL9091759 | 0.80 | HRH1 (0.48) | HRH1TACR2TACR1TACR3 | |
| SCHEMBL6999634 | 0.79 | TACR2 (0.57) | HRH1TACR2TACR1TACR3 | |
| SCHEMBL9027870 | 0.78 | TACR2 (0.56) | HRH1TACR2TACR1TACR3 | |
| SCHEMBL27412215 | 0.78 | PKM (0.39) | HRH1 | |
| SCHEMBL27405658 | 0.78 | L3MBTL1 (0.43) | HRH1TACR2TACR1TACR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5563133-A | NERVOUS SYSTEM DISORDERS | ELI LILLY AND COMPANY (US) | 1996-10-08 | — | — | US | disclosed |
| EP-0714891-A1 | Heterocyclic tachykinin receptor antagonists | ELI LILLY AND COMPANY (US) | 1996-06-05 | — | — | EP | disclosed |