SCHEMBL9028073

SCHEMBL9028073

C=CCc1c2c(c(C)c(OCc3ccccc3)c1C(C)(C)C)CC(C)(C)O2

nearest known ligand 0.35

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
MAOB P27338 1/20 0.35
GAA P10253 2/20 0.32
LMNA P02545 1/20 0.32
MAPT P10636 2/20 0.32
TDP1 Q9NUW8 2/20 0.32
L3MBTL1 Q9Y468 2/20 0.32
MAPK1 P28482 1/20 0.32
ALDH1A1 P00352 1/20 0.30
HPGD P15428 1/20 0.30
CYP1A2 P05177 1/20 0.30
ALOX15 P16050 1/20 0.30
CYP2C19 P33261 1/20 0.30
NPC1 O15118 1/20 0.30
RAB9A P51151 1/20 0.30
FEN1 P39748 1/20 0.30
HPD P32754 1/20 0.30
OPRM1 P35372 1/20 0.30
OPRD1 P41143 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9028599 0.93 MAOB (0.35) MAOBGAALMNAMAPTTDP1
SCHEMBL9029180 0.89 MAOB (0.38) MAOBGAALMNAMAPTTDP1
SCHEMBL9026986 0.85 MAOB (0.36) MAOBGAALMNAALDH1A1NPC1
SCHEMBL9029111 0.84 LTA4H (0.38) MAOBGAALMNAMAPTTDP1
SCHEMBL9028284 0.81 MAOB (0.34) MAOBGAALMNAMAPTTDP1
SCHEMBL9028229 0.81 MAOB (0.32) MAOB
SCHEMBL9027608 0.80 MAOB (0.35) MAOBGAALMNAALDH1A1CYP1A2
SCHEMBL9028949 0.80 LTA4H (0.37) MAOBGAALMNAMAPTTDP1
SCHEMBL9028093 0.79 MAOB (0.38) MAOBMAPTTDP1L3MBTL1MAPK1
SCHEMBL9028097 0.78 MAOB (0.36) MAOBGAALMNAMAPTTDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0445827-B1 4-Hydroxytetrahydropyran-2-one derivatives useful as cholesterol and lipid reducing agents FUJIREBIO KK (JP) 1996-09-25 EP disclosed
US-5149834-A Anticholesterol agent and enzyme inhibitors, for curing arteriosclerosis FUJIREBIO INC. (JP) 1992-09-22 US disclosed
EP-0445827-A2 4-Hydroxytetrahydropyran-2-one derivatives useful as cholesterol and lipid reducing agents FUJIREBIO INC. (JP) 1991-09-11 EP disclosed