Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KARS1 | Q15046 | 13/20 | 0.49 |
| ▸ | ACHE | P22303 | 1/20 | 0.42 |
| ▸ | CKS1B | P61024 | 1/20 | 0.42 |
| ▸ | SKP1 | P63208 | 1/20 | 0.42 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.42 |
| ▸ | YAP1 | P46937 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL902899 | 0.94 | KARS1 (0.47) | KARS1ACHECKS1BSKP1SKP2 | |
| SCHEMBL1704312 | 0.90 | KARS1 (0.48) | KARS1ACHECKS1BSKP1SKP2 | |
| SCHEMBL901814 | 0.86 | KARS1 (0.66) | KARS1 | |
| SCHEMBL901882 | 0.86 | KARS1 (0.48) | KARS1ACHE | |
| SCHEMBL901508 | 0.85 | KARS1 (0.56) | KARS1CKS1BSKP1SKP2 | |
| SCHEMBL1704341 | 0.85 | KARS1 (0.55) | KARS1ACHECKS1BSKP1SKP2 | |
| SCHEMBL1704453 | 0.84 | KARS1 (0.52) | KARS1CKS1BSKP1SKP2 | |
| SCHEMBL1704481 | 0.83 | KARS1 (0.55) | KARS1ACHECKS1BSKP1SKP2 | |
| SCHEMBL1704577 | 0.83 | KARS1 (0.56) | KARS1ACHECKS1BSKP1SKP2 | |
| SCHEMBL902972 | 0.83 | KARS1 (0.51) | KARS1CKS1BSKP1SKP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2441755-A1 | Pyridine- and isoquinoline-derivatives as Syk and JAK kinase inhibitors | Almirall, S.A. (ES) | 2012-04-18 | — | — | EP | disclosed |
| WO-2012041476-A1 | PYRIDINE AND ISOQUINOLINE DERIVATIVES AS SYK- AND JAK-KINASE INHIBITORS | ALMIRALL, S.A. (ES) | 2012-04-05 | — | — | WO | disclosed |