Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2A | P11388 | 2/20 | 0.48 |
| ▸ | TOP2B | Q02880 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 3/20 | 0.34 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | BRD4 | O60885 | 3/20 | 0.33 |
| ▸ | PRPS1 | P60891 | 2/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.31 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.31 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.31 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.31 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | CDK9 | P50750 | 1/20 | 0.31 |
| ▸ | NAMPT | P43490 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | KDR | P35968 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14029046 | 0.74 | TOP2A (0.78) | TOP2ATOP2BLMNAADRA2AADRA2B | |
| SCHEMBL9040766 | 0.70 | NISCH (0.46) | TOP2ATOP2BTSHRGAA | |
| SCHEMBL9028183 | 0.70 | TOP2A (0.49) | TOP2ATOP2BLMNAHSD17B10MAPT | |
| SCHEMBL9029007 | 0.70 | TOP2A (0.49) | TOP2ATOP2BLMNAHSD17B10MAPT | |
| SCHEMBL9112632 | 0.70 | TOP2A (0.49) | TOP2ATOP2BLMNAHSD17B10MAPT | |
| SCHEMBL9112379 | 0.70 | TOP2A (0.49) | TOP2ATOP2BLMNAHSD17B10MAPT | |
| SCHEMBL9114197 | 0.70 | TOP2A (0.58) | TOP2ATOP2BLMNAHSD17B10MAPT | |
| SCHEMBL9113764 | 0.70 | TOP2A (0.58) | TOP2ATOP2BLMNAHSD17B10MAPT | |
| Hydrochloric Acid SCHEMBL11547564 | 0.69 | TOP2A (0.59) | TOP2ATOP2BLMNAHSD17B10MAPT | |
| SCHEMBL14153121 | 0.68 | TOP2A (0.68) | TOP2ATOP2BLMNAADRA2AADRA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0720603-A1 | BIS(AMIDINOBENZIMIDAZOLYL)ALKANES AS ANTIVIRAL AGENTS | THE WELLCOME FOUNDATION LIMITED (GB) | 1996-07-10 | — | — | EP | disclosed |