Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2A | P11388 | 2/20 | 0.49 |
| ▸ | TOP2B | Q02880 | 2/20 | 0.49 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 3/20 | 0.34 |
| ▸ | NPC1 | O15118 | 2/20 | 0.32 |
| ▸ | RAB9A | P51151 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.32 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.32 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.32 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.32 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | TPSAB1 | Q15661 | 3/20 | 0.31 |
| ▸ | F2 | P00734 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9112632 | 1.00 | TOP2A (0.49) | TOP2ATOP2BAAK1LMNANPC1 | |
| SCHEMBL9112379 | 1.00 | TOP2A (0.49) | TOP2ATOP2BAAK1LMNANPC1 | |
| SCHEMBL9029007 | 1.00 | TOP2A (0.49) | TOP2ATOP2BAAK1LMNANPC1 | |
| SCHEMBL9111081 | 0.94 | TOP2A (0.44) | TOP2ATOP2BAAK1LMNANPC1 | |
| SCHEMBL14029046 | 0.75 | TOP2A (0.78) | TOP2ATOP2BLMNANPC1RAB9A | |
| SCHEMBL9081982 | 0.72 | TOP2A (0.54) | TOP2ATOP2BAAK1LMNANPC1 | |
| SCHEMBL9029321 | 0.71 | NPC1 (0.34) | AAK1LMNANPC1RAB9AMAPT | |
| SCHEMBL9114197 | 0.71 | TOP2A (0.58) | TOP2ATOP2BLMNANPC1RAB9A | |
| SCHEMBL9113764 | 0.71 | TOP2A (0.58) | TOP2ATOP2BLMNANPC1RAB9A | |
| SCHEMBL9028178 | 0.70 | TOP2A (0.48) | TOP2ATOP2BLMNAMAPTADRA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0720603-A1 | BIS(AMIDINOBENZIMIDAZOLYL)ALKANES AS ANTIVIRAL AGENTS | THE WELLCOME FOUNDATION LIMITED (GB) | 1996-07-10 | — | — | EP | disclosed |
| WO-1995008540-A1 | BIS(AMIDINOBENZIMIDAZOLYL)ALKANES AS ANTIVIRAL AGENTS | THE WELLCOME FOUNDATION LIMITED (GB) | 1995-03-30 | — | — | WO | disclosed |