Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 12/20 | 0.46 |
| ▸ | GLRA1 | P23415 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 3/20 | 0.34 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | MAOA | P21397 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9029058 | 0.81 | MAOB (0.46) | MAOBGLRA1LMNAGAAALDH1A1 | |
| SCHEMBL9028403 | 0.81 | MAOB (0.46) | MAOBLMNAGAAALDH1A1KDM4E | |
| SCHEMBL9028968 | 0.77 | MAOB (0.37) | MAOBGLRA1LMNAGAAALDH1A1 | |
| SCHEMBL9028467 | 0.75 | MAOB (0.37) | MAOBGLRA1LMNAGAAALDH1A1 | |
| SCHEMBL9028395 | 0.75 | MAOB (0.38) | MAOBGLRA1LMNAGAAALDH1A1 | |
| SCHEMBL9029047 | 0.74 | LTA4H (0.38) | MAOBGLRA1LMNAGAAALDH1A1 | |
| SCHEMBL9029066 | 0.74 | MAOB (0.45) | MAOBLMNAGAAALDH1A1KDM4E | |
| SCHEMBL9028097 | 0.73 | MAOB (0.36) | MAOBGLRA1LMNAGAAALDH1A1 | |
| SCHEMBL9028175 | 0.73 | MAOB (0.38) | MAOBGLRA1LMNAGAAALDH1A1 | |
| SCHEMBL9028553 | 0.72 | MAOB (0.33) | MAOBNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0445827-B1 | 4-Hydroxytetrahydropyran-2-one derivatives useful as cholesterol and lipid reducing agents | FUJIREBIO KK (JP) | 1996-09-25 | — | — | EP | disclosed |
| US-5149834-A | Anticholesterol agent and enzyme inhibitors, for curing arteriosclerosis | FUJIREBIO INC. (JP) | 1992-09-22 | — | — | US | disclosed |
| EP-0445827-A2 | 4-Hydroxytetrahydropyran-2-one derivatives useful as cholesterol and lipid reducing agents | FUJIREBIO INC. (JP) | 1991-09-11 | — | — | EP | disclosed |