Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 6/20 | 0.52 |
| ▸ | RAB9A | P51151 | 6/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.52 |
| ▸ | MEN1 | O00255 | 4/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.52 |
| ▸ | MAPT | P10636 | 4/20 | 0.52 |
| ▸ | TP53 | P04637 | 3/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.52 |
| ▸ | IDO1 | P14902 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.45 |
| ▸ | NCF1 | P14598 | 3/20 | 0.45 |
| ▸ | NOS2 | P35228 | 1/20 | 0.45 |
| ▸ | BACE1 | P56817 | 1/20 | 0.45 |
| ▸ | CA12 | O43570 | 1/20 | 0.45 |
| ▸ | CA9 | Q16790 | 1/20 | 0.45 |
| ▸ | AR | P10275 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29390450 | 1.00 | NPC1 (0.52) | NPC1RAB9AALDH1A1CYP3A4MEN1 | |
| SCHEMBL3525605 | 0.92 | NPC1 (0.49) | NPC1RAB9AALDH1A1CYP3A4MEN1 | |
| SCHEMBL20623032 | 0.90 | NPC1 (0.47) | NPC1RAB9AALDH1A1CYP3A4MEN1 | |
| SCHEMBL3524818 | 0.90 | NPC1 (0.47) | NPC1RAB9AALDH1A1CYP3A4MEN1 | |
| SCHEMBL20615088 | 0.90 | NPC1 (0.47) | NPC1RAB9AALDH1A1CYP3A4MEN1 | |
| SCHEMBL12533920 | 0.87 | ALDH1A1 (0.52) | NPC1RAB9AALDH1A1CYP3A4MEN1 | |
| SCHEMBL12533917 | 0.87 | ALDH1A1 (0.52) | NPC1RAB9AALDH1A1CYP3A4MEN1 | |
| SCHEMBL12533914 | 0.87 | ALDH1A1 (0.52) | NPC1RAB9AALDH1A1CYP3A4MEN1 | |
| SCHEMBL21000902 | 0.87 | MEN1 (0.57) | NPC1RAB9AALDH1A1CYP3A4MEN1 | |
| SCHEMBL29733200 | 0.87 | MEN1 (0.57) | NPC1RAB9AALDH1A1CYP3A4MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119930511-A | Method for synthesizing N-heterocyclic compound by manganese complex catalysis under mild condition | 浙江工业大学 | 2025-05-06 | — | — | CN | disclosed |
| EP-4274828-A1 | MODULATORS OF THE CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR PROTEIN AND METHODS OF USE | AbbVie Global Enterprises Ltd. (BM) | 2023-11-15 | — | — | EP | disclosed |
| WO-2022150174-A1 | MODULATORS OF THE CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR PROTEIN AND METHODS OF USE | AbbVie Global Enterprises Ltd. (BM) | 2022-07-14 | — | — | WO | disclosed |
| CN-107400084-B | Method for synthesizing quinoline derivative | 南京理工大学 | 2020-04-10 | — | — | CN | disclosed |
| CN-106749403-B | A kind of flame-retardant luminous bifunctional material of difluorophenyl quinoline phosphine oxide and preparation method thereof | 广东省测试分析研究所（中国广州分析测试中心） | 2019-03-01 | — | — | CN | disclosed |
| CN-103288833-B | Imidazo-triazine and imidazopyrimidine as kinase inhibitor | 因塞特控股公司 | 2018-01-12 | — | — | CN | disclosed |
| EP-2621276-B1 | 2-ALKOXY PYRIMIDINE PDE10 INHIBITORS | MERCK SHARP & DOHME (US) | 2017-12-27 | — | — | EP | disclosed |
| CN-107400084-A | A kind of method of synthesis of quinoline derivatives | 南京理工大学 | 2017-11-28 | — | — | CN | disclosed |
| EP-2621926-B1 | PYRAZOLOPYRIMIDINE PDE10 INHIBITORS | MERCK SHARP & DOHME (US) | 2017-08-30 | — | — | EP | disclosed |
| CN-103214481-B | Novel imidazole also [1,2-a] pyridine compounds and their, its preparation method, comprise the medical composition and its use of this compounds | 中国科学院上海药物研究所 | 2016-08-03 | — | — | CN | disclosed |
| CN-103242317-A | Salt of cyclopropyl quinoline derivative | SHANGHAI YIZHI MEDICAL TECH CO | 2013-08-14 | — | — | CN | disclosed |
| CN-103242317-A | Salt of cyclopropyl quinoline derivative | SHANGHAI YIZHI MEDICAL TECH CO | 2013-08-14 | — | — | CN | disclosed |
| CN-103214481-A | Novel imidazo[1,2-a]pyridines compound, preparation method, pharmaceutical composition containing imidazo[1,2-a]pyridines compound and application | SHANGHAI INST MATERIA MEDICA | 2013-07-24 | — | — | CN | disclosed |
| CN-101641093-B | Imidazotriazines and imidazopyrimidines as kinase inhibitors | INCYTE CORP | 2013-05-29 | — | — | CN | disclosed |
| WO-2012162213-A1 | ARYLOXYMETHYL CYCLOPROPANE DERIVATIVES AS PDE10 INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2012-11-29 | — | — | WO | disclosed |
| WO-2012044562-A2 | PYRAZOLOPYRIMIDINE PDE10 INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2012-04-05 | — | — | WO | disclosed |
| WO-2012044561-A2 | 2-ALKOXY PYRIMIDINE PDE10 INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2012-04-05 | — | — | WO | disclosed |
| CN-101641093-A | Imidazotriazines and imidazopyrimidines as kinase inhibitors | INCYTE CORP US | 2010-02-03 | — | — | CN | disclosed |
| EP-2099447-A1 | IMIDAZOTRIAZINES AND IMIDAZOPYRIMIDINES AS KINASE INHIBITORS | Incyte Corporation (US) | 2009-09-16 | — | — | EP | disclosed |
| WO-2008064157-A1 | IMIDAZOTRIAZINES AND IMIDAZOPYRIMIDINES AS KINASE INHIBITORS | INCYTE CORPORATION (US) | 2008-05-29 | — | — | WO | disclosed |